Bioconjugate Chemistry 1993-01-01

p-maleimidophenyl isocyanate: a novel heterobifunctional linker for hydroxyl to thiol coupling.

M E Annunziato, U S Patel, M Ranade, P S Palumbo

文献索引：Bioconjug. Chem. 4 , 212, (1993)

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摘要

p-Maleimidophenyl isocyanate (PMPI, 1) is a heterobifunctional cross-linking agent useful for thiol to hydroxyl coupling. Several maleimide-activated compounds were prepared and characterized and then shown to be reactive with thiol-containing proteins. Examples include activation of vitamin B12, digoxigenin, digitoxigenin, estradiol, progesterone, and some serine-containing peptides.

相关化合物

  • 4 -(马来酰亚胺基)...

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