亚磷酸三苯酯

亚磷酸三苯酯用途

【用途一】
用作合成橡胶和树脂的稳定剂，聚氯乙烯塑料的抗氧剂及醇酸树脂和农药中间体的原料
【用途二】
用作螯合剂、塑料制品防老剂及合成醇酸树酯和聚酯树脂的原料
【用途三】
辅助抗氧剂，具有光稳定效果，适用于聚氯乙烯、聚丙烯、聚苯乙烯，聚酯、ABS树脂、环氧树脂等。在聚氯乙烯制品中作螯合剂，能使制品保持透明度，并能抑制颜色变化。也可用于亚磷酸三甲酯的生产。
【用途四】
螯合剂，广泛用于各种PVC制品中，能使制品保持其透明度并能抑制颜色的变化，同时它可增加主稳定剂的抗氧性和光、热稳定性。另外，本品还用于PE、PP、ABS、SBS等制品中，并可作农药中间体。合成醇酸树脂和聚酯和聚酯树脂的原料。

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亚磷酸三苯酯名称

[ CAS 号 ]:
101-02-0

[ 中文名 ]:
亚磷酸三苯酯

[ 英文名 ]:
Triphenyl phosphite

[中文别名 ]:

三苯氧基磷

[英文别名 ]:

EFED
Triphenyl phosphite
jp360
EINECS 202-908-4
p36
TPO
westontpp
mellite310
MFCD00002080
Phosphorous acid, triphenyl ester

亚磷酸三苯酯物理化学性质

[ 密度 ]:
1.184 g/mL at 25 °C(lit.)

[ 沸点 ]:
360.0±11.0 °C at 760 mmHg

[ 熔点 ]:
22-24 °C(lit.)

[ 分子式 ]:
C₁₈H₁₅O₃P

[ 分子量 ]:
310.284

[ 闪点 ]:
218.3±0.0 °C

[ 精确质量 ]:
310.075867

[ PSA ]:
41.28000

[ LogP ]:
7.43

[ 外观性状 ]:
无色至淡黄色液体

[ 蒸汽密度 ]:
10.7 (vs air)

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
n20/D 1.59(lit.)

[ 储存条件 ]:
-20°C

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
insoluble

亚磷酸三苯酯MSDS

详细MSDS(安全技术说明书)

亚磷酸三苯酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TH1575000

CHEMICAL NAME :: Phosphorous acid, triphenyl ester

CAS REGISTRY NUMBER :: 101-02-0

BEILSTEIN REFERENCE NO. :: 1079456

LAST UPDATED :: 199710

DATA ITEMS CITED :: 27

MOLECULAR FORMULA :: C18-H15-O3-P

MOLECULAR WEIGHT :: 310.30

WISWESSER LINE NOTATION :: ROPOR&OR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 5,311,1952

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 5,311,1952

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1117,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1117,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 444 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(12),13,1981

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6700 mg/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0532280

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1117,1986

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - tremor Behavioral - muscle weakness

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 49,78,1933

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1490 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - changes in motor activity (specific assay)

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 21(9),55,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1080 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(12),53,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 266 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 31,1288,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1360 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - changes in motor activity (specific assay)

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 21(9),55,1977

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity) Behavioral - tremor

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570901

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 49,78,1933

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0532280

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0532280

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 375 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Behavioral - ataxia

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0532280

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Behavioral - convulsions or effect on seizure threshold Cardiac - other changes

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 5,311,1952 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3552 mg/kg/7D-I

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - ataxia

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 29,110,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 5 gm/kg/5D-I

TOXIC EFFECTS :: Behavioral - ataxia Skin and Appendages - dermatitis, other (after systemic exposure) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0532280

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 9 mg/m3/4H/45D-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 21(9),55,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82978 No. of Facilities: 394 (estimated) No. of Industries: 15 No. of Occupations: 34 No. of Employees: 10448 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82978 No. of Facilities: 6115 (estimated) No. of Industries: 45 No. of Occupations: 46 No. of Employees: 84276 (estimated) No. of Female Employees: 6323 (estimated)

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亚磷酸三苯酯安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H317-H319-H410

[ 警示性声明 ]:
P280-P301 + P312 + P330-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi:Irritant;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R36/38;R50/53

[ 安全声明 (欧洲) ]:
S28-S60-S61-S28A

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
TH1575000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

[ 海关编码 ]:
2920901900

亚磷酸三苯酯合成路线

详细合成路线

亚磷酸三苯酯上下游产品

亚磷酸三苯酯上游产品

亚磷酸三苯酯下游产品

亚磷酸三苯酯制备

1. 三氯氧磷直接法(又称热法) 苯酚以吡啶和无水苯为溶剂，在不超过10℃的温度下，缓缓加入氧氯化磷，然后在回流温度下，反应3～4h。冷却至室温后，反应物经水洗回收吡啶，离心脱水后，再用干燥的硫酸钠脱水，过滤除去硫酸钠。最后先常压蒸馏回收苯，再减压蒸馏，收集243～245℃(1.47kPa)的馏分，经冷却、结晶、粉碎即为成品。

2. 三氯化磷间接法(又称冷法) 苯酚熔融后，搅拌下在25℃下滴加三氯化磷，生成亚磷酸三苯酯；然后升温至70℃通入氯气，生成二氯代磷酸三苯酯；再于50℃加水水解，生成磷酸三苯酯。最后水解产物用5%纯碱水溶液进行中和、水洗、蒸发和减压蒸馏，收集243～245℃(1.47kPa)的馏分，冷却、结晶、粉碎、包装即为成品。

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亚磷酸三苯酯海关

[ 海关编码 ]: 2920901900

[ 中文概述 ]:
2920901900 亚磷酸酯。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2920901900 VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

亚磷酸三苯酯文献

Triphenyl phosphite, a new allergen in polyvinylchloride gloves.

Contact Dermatitis 68(1) , 42-9, (2013)

Contact allergy to polyvinylchloride (PVC) gloves has been reported relatively seldom. In spring 2011, 5 of our patients had patch test reactions to PVC gloves. We obtained a collection of PVC raw mat...

Bioluminescent liquid light guide pad biosensor for indoor air toxicity monitoring.

Anal. Chem. 87(7) , 3655-61, (2015)

Indoor air pollution became a recent concern found to be oftentimes worse than outdoor air quality. We developed a tool that is cheap and simple and enables continuous monitoring of air toxicity. It i...

Synthesis of tetra-substituted imidazoles and 2-imidazolines by Ni(0)-catalyzed dehydrogenation of benzylic-type imines.

Dalton Trans. 43(42) , 15997-6005, (2014)

Ni(0)-catalyzed dehydrogenation of benzylic-type imines was performed to yield asymmetrical tetra-substituted imidazoles and 2-imidazolines. This was achieved with a single operational step while main...

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亚磷酸三苯酯

亚磷酸三苯酯用途

亚磷酸三苯酯名称

亚磷酸三苯酯物理化学性质

亚磷酸三苯酯MSDS

详细MSDS(安全技术说明书)

亚磷酸三苯酯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

亚磷酸三苯酯安全信息

亚磷酸三苯酯合成路线

详细合成路线

亚磷酸三苯酯上下游产品

亚磷酸三苯酯上游产品

亚磷酸三苯酯下游产品

亚磷酸三苯酯制备

亚磷酸三苯酯海关

亚磷酸三苯酯文献

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