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n-乙酰-d-苯丙氨酸

n-乙酰-d-苯丙氨酸用途

【用途一】
手性化工原料和医药中间体。它是用于合成治疗Ⅱ型糖尿病的首选药物那格列。

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n-乙酰-d-苯丙氨酸名称

[ CAS 号 ]:
10172-89-1

[ 中文名 ]:
N-乙酰-D-苯丙氨酸

[ 英文名 ]:
Ac-D-Phe-OH

[中文别名 ]:

[英文别名 ]:

D-Phenylalanine, N-acetyl-
N-Acetyl-D-phenylalanine
MFCD00002664
Acetyl-D-Phenylalanine
(2R)-2-acetamido-3-phenylpropanoic acid
Ac-D-Phe-OH
EINECS 233-447-7

n-乙酰-d-苯丙氨酸生物活性

[ 描述 ]:

N-乙酰-D-苯丙氨酸是苯丙氨酸衍生物[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

氨基酸和氨基酸衍生物已被商业化用作能量补充剂。它们影响合成代谢激素的分泌、运动期间的燃料供应、压力相关任务期间的精神表现,并防止运动引起的肌肉损伤。它们被认为是有益的能生膳食物质[1]。

[参考文献]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807.

n-乙酰-d-苯丙氨酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
453.9±38.0 °C at 760 mmHg

[ 熔点 ]:
167ºC

[ 分子式 ]:
C₁₁H₁₃NO₃

[ 分子量 ]:
207.226

[ 闪点 ]:
228.3±26.8 °C

[ 精确质量 ]:
207.089539

[ PSA ]:
66.40000

[ LogP ]:
0.78

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.548

[ 储存条件 ]:
−20°C

n-乙酰-d-苯丙氨酸MSDS

n-乙酰-d-苯丙氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2924299090

n-乙酰-d-苯丙氨酸合成路线

n-乙酰-d-苯丙氨酸上下游产品

n-乙酰-d-苯丙氨酸上游产品

n-乙酰-d-苯丙氨酸下游产品

n-乙酰-d-苯丙氨酸海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

n-乙酰-d-苯丙氨酸文献

Peptide synthesis catalyzed by an antibody containing a binding site for variable amino acids.

Science 265 , 234, (1994)

Monoclonal antibodies, induced with a phosphonate diester hapten, catalyzed the coupling of p-nitrophenyl esters of N-acetyl valine, leucine, and phenylalanine with tryptophan amide to form the corres...

Studies on the mechanism for renal elimination of N-acetylphenylalanine: its pathophysiologic significance in phenylketonuria.

J. Lab. Clin. Med. 105(1) , 132-8, (1985)

To elucidate the mechanism and biologic significance of urinary occurrence of N-acetylphenylalanine in phenylketonuria, the metabolic fate of N-acetylphenylalanine was studied in rats. In vivo and in ...

Molecular dynamics (MD) simulations for the prediction of chiral discrimination of N-acetylphenylalanine enantiomers by cyclomaltoheptaose (beta-cyclodextrin, beta-CD) based on the MM-PBSA (molecular mechanics-Poisson-Boltzmann surface area) approach.

Carbohydr. Res. 339(11) , 1961-6, (2004)

Molecular dynamics (MD) simulations were performed for the prediction of chiral discrimination of N-acetylphenylalanine enantiomers by cyclomaltoheptaose (beta-cyclodextrin, beta-CD). Binding free ene...

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