2-(1,3-benzodioxol-5-yl)-3-[3-(2-methylpropylamino)propyl]-1,3-thiazolidin-4-one,hydrochloride

名称

[ CAS 号 ]:
102612-94-2

[ 英文名 ]:
2-(1,3-benzodioxol-5-yl)-3-[3-(2-methylpropylamino)propyl]-1,3-thiazolidin-4-one,hydrochloride

[英文别名 ]:

WIN 2661

物理化学性质

[ 沸点 ]:
517.5ºC at 760mmHg

[ 分子式 ]:
C₁₇H₂₅ClN₂O₃S

[ 分子量 ]:
372.91000

[ 闪点 ]:
266.8ºC

[ 精确质量 ]:
372.12700

[ PSA ]:
76.10000

[ LogP ]:
3.75580

[ 蒸汽压 ]:
8.15E-11mmHg at 25°C

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ6277000

CHEMICAL NAME :: 4-Thiazolidinone, 3-(3-(isobutylamino)propyl)-2-(3,4-methylenedioxyphen yl)-, monohydrochloride

CAS REGISTRY NUMBER :: 102612-94-2

LAST UPDATED :: 198609

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H24-N2-O3-S.Cl-H

MOLECULAR WEIGHT :: 372.95

WISWESSER LINE NOTATION :: T56 BO DO CHJ H- ET5NV DSTJ A3M1Y1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 40,132,1951 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 40,132,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 123,269,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 40,132,1951

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