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D-肌醇-1,3,4,5-四(磷酸)铵盐

D-肌醇-1,3,4,5-四(磷酸)铵盐用途

肌醇1,3,4,5-四磷酸是PIP3(磷脂酰肌醇3,4,5-三磷酸)的头基[1]。

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D-肌醇-1,3,4,5-四(磷酸)铵盐名称

[ CAS 号 ]:
102850-29-3

[ 中文名 ]:
D-肌醇-1,3,4,5-四(磷酸)铵盐

[ 英文名 ]:
Inositol 1,3,4,5-tetraphosphate

[英文别名 ]:

myo-inositol 1,3,4,5-tetrakisphosphate
INOSITOLTETRAPHOSPHATE
inositol-1,3,4,5-tetrakisphosphate
IP4
InsP4
D-myo-Inositol 1,3,4,5-tetrakisphosphoric acid
Inositol 1,3,4,5-tetrakishosphate

D-肌醇-1,3,4,5-四(磷酸)铵盐生物活性

[ 描述 ]:

肌醇1,3,4,5-四磷酸是PIP3(磷脂酰肌醇3,4,5-三磷酸)的头基[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Liu J, et al. Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation. J Biol Chem. 2011;286(50):43334-43342.

D-肌醇-1,3,4,5-四(磷酸)铵盐物理化学性质

[ 密度 ]:
2.32 g/cm3

[ 沸点 ]:
1015.6ºC at 760 mmHg

[ 分子式 ]:
C₆H₁₆O₁₈P₄

[ 分子量 ]:
517.10600

[ 闪点 ]:
568ºC

[ 精确质量 ]:
516.95500

[ PSA ]:
349.98000

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.632

D-肌醇-1,3,4,5-四(磷酸)铵盐MSDS

详细MSDS(安全技术说明书)

D-肌醇-1,3,4,5-四(磷酸)铵盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

D-肌醇-1,3,4,5-四(磷酸)铵盐文献

IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice.

Blood 125 , 2786-97, (2015)

Tight regulation of hematopoietic stem cell (HSC) homeostasis ensures lifelong hematopoiesis and prevents blood cancers. The mechanisms balancing HSC quiescence with expansion and differentiation into...

Cell signaling. The art of the soluble.

Science 316(5826) , 845-6, (2007)

Interaction of the brain-specific protein p42IP4/centaurin-alpha1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, with stereospecificity.

J. Neurochem. 98(2) , 343-54, (2006)

The brain-specific protein p42IP4, also called centaurin-alpha1, specifically binds phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] and inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4]. ...

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