二溴甘露醇
二溴甘露醇名称
[ CAS 号 ]:
10318-26-0
[ 中文名 ]:
二溴甘露醇
[ 英文名 ]:
Galactitol,1,6-dibromo-1,6-dideoxy-
[英文别名 ]:
- 1,6-Dibromodulcitol
- 1,6-Dibrom-1,6-didesoxy-galactit
- Mitolactol
- Dibromdulcitol
- Dibromdulcit
- 1,6-Dibrom-galacto-hexan-2,3,4,5-tetraol
- 1,6-Dibromodideoxydulcitol
- 1,6-dibromo-1,6-dideoxygalactitol
- dibromodulcitol
- Elobromol
二溴甘露醇物理化学性质
[ 密度 ]:
2.117g/cm3
[ 沸点 ]:
511.2ºC at 760mmHg
[ 熔点 ]:
183-185ºC
[ 分子式 ]:
C6H12Br2O4
[ 分子量 ]:
307.96500
[ 闪点 ]:
263ºC
[ 精确质量 ]:
305.91000
[ PSA ]:
80.92000
[ 蒸汽压 ]:
1.37E-12mmHg at 25°C
[ 折射率 ]:
1.622
二溴甘露醇毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LW5425000
- CHEMICAL NAME :
- Galactitol, 1,6-dibromo-1,6-dideoxy-
- CAS REGISTRY NUMBER :
- 10318-26-0
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 20
- MOLECULAR FORMULA :
- C6-H12-Br2-O4
- MOLECULAR WEIGHT :
- 308.00
- WISWESSER LINE NOTATION :
- E1YQYQYQYQ1E
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 72 mg/kg/D
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 470 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1238 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 550 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - protects against induction of experimental tumors
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 700 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5850 mg/kg/26W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3500 mg/kg/26W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- DNA adduct
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - rabbit Bone marrow
- DOSE/DURATION :
- 390 umol/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 25,1705,1976
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