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(R)-左乙拉西坦

(R)-左乙拉西坦名称

[ CAS 号 ]:
103765-01-1

[ 中文名 ]:
(R)-2-(2-氧代吡咯烷-1-基)丁酰胺

[ 英文名 ]:
Etiracetam

[中文别名 ]:

左乙拉西坦杂质D

[英文别名 ]:

1-Pyrrolidineacetamide, α-ethyl-2-oxo-
(2R)-2-(2-Oxo-1-pyrrolidinyl)butanimidic acid
Etiracetam, R-(+)-
(±)-a-Ethyl-2-oxo-1-pyrrolidineacetamide
(2R)-2-(2-oxopyrrolidin-1-yl)butanamide
T5NVTJ AY2&VZ
(R)-2-(2-oxopyrrolidin-1-yl)butanamide
Etiracetam
1-Pyrrolidineacetamide, α-ethyl-2-oxo-, (αR)-
2-(2-Oxo-1-pyrrolidinyl)butanamide

(R)-左乙拉西坦物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
395.9±25.0 °C at 760 mmHg

[ 分子式 ]:
C₈H₁₄N₂O₂

[ 分子量 ]:
170.209

[ 闪点 ]:
193.2±23.2 °C

[ 精确质量 ]:
170.105530

[ PSA ]:
64.39000

[ LogP ]:
-0.67

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.519

(R)-左乙拉西坦文献

Inhibition of excitatory synaptic transmission in hippocampal neurons by levetiracetam involves Zn²⁺-dependent GABA type A receptor-mediated presynaptic modulation.

J. Pharmacol. Exp. Ther. 348(2) , 246-59, (2014)

Levetiracetam (LEV) is an antiepileptic drug with a unique but as yet not fully resolved mechanism of action. Therefore, by use of a simplified rat-isolated nerve-bouton preparation, we have investiga...

Efficacy and safety of pregabalin versus levetiracetam as adjunctive therapy in patients with partial seizures: a randomized, double-blind, noninferiority trial.

Epilepsia 55(7) , 1048-57, (2014)

To assess the comparative efficacy and safety of pregabalin and levetiracetam for the reduction of seizure frequency in patients with partial seizures.This was a randomized, double-blind, flexible-dos...

[Epilepsy in the elderly].

Tidsskr. Nor. Laegeforen. 133(5) , 528-31, (2013)

Diagnostic work-up and treatment of patients who have developed epilepsy after the age of 65 can both be difficult. Epilepsy is one of the most common neurological conditions in the elderly, and the i...

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(R)-左乙拉西坦

(R)-左乙拉西坦名称

(R)-左乙拉西坦物理化学性质

(R)-左乙拉西坦文献

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