环丙基[4-[3-(1H-咪唑-5-基)丙氧基]苯基]甲酮盐酸盐

用途

Ciproxifan belongs to a novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.

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名称

[ CAS 号 ]:
1049741-81-2

[ 中文名 ]:
盐酸环丙沙星

[ 英文名 ]:
Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone hydrochloride

[英文别名 ]:

物理化学性质

[ 分子式 ]:
C₁₆H₁₉ClN₂O₂

[ 分子量 ]:
306.78700

[ 精确质量 ]:
306.11400

[ PSA ]:
54.98000

[ LogP ]:
3.81600

[ 外观性状 ]:
固体

[ 储存条件 ]:
2-8°C

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Ciproxifan differentially modifies cognitive impairment evoked by chronic stress and chronic corticosterone administration in rats.

Behav. Brain Res. 283 , 145-53, (2015)

Despite the development of neuroscience and spectacular discoveries, the clear functions and the role of histamine are still not fully understood, especially in the context of the negative impact of p...

更多文献

环丙基[4-[3-(1H-咪唑-5-基)丙氧基]苯基]甲酮盐酸盐

用途

名称

物理化学性质

MSDS

详细MSDS(安全技术说明书)

安全信息

文献

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