溴乙酸乙酯

【用途一】
用作医药、农药中间体
【用途二】
用于有机合成

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
168.5±0.0 °C at 760 mmHg

[ 熔点 ]:
-38 °C

[ 分子式 ]:
C₄H₇BrO₂

[ 分子量 ]:
167.001

[ 闪点 ]:
47.8±0.0 °C

[ 精确质量 ]:
165.962936

[ PSA ]:
26.30000

[ LogP ]:
1.37

[ 外观性状 ]:
无色至淡黄色液体

[ 蒸汽压 ]:
1.6±0.3 mmHg at 25°C

[ 折射率 ]:
1.453

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类、食品添加剂分开存放

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, water, strong acids.

[ 水溶解性 ]:
混溶：乙醚,乙醇；可溶于：苯,丙酮

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

AF6000000

CHEMICAL NAME :

Acetic acid, bromo-, ethyl ester

CAS REGISTRY NUMBER :

105-36-2

BEILSTEIN REFERENCE NO. :

0506456

LAST UPDATED :

199701

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C4-H7-Br-O2

MOLECULAR WEIGHT :

167.02

WISWESSER LINE NOTATION :

E1VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

252 mg/kg/63W-I

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :

JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 53,695,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4664 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 851 (estimated) No. of Female Employees: 187 (estimated)

[ 符号 ]:

GHS02, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H300 + H310 + H330

[ 警示性声明 ]:
Missing Phrase - N15.00950417-P210-P280-P302 + P352 + P310-P304 + P340 + P310-P370 + P378

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T+:Verytoxic;

[ 风险声明 (欧洲) ]:
R26/27/28

[ 安全声明 (欧洲) ]:
S26-S45-S7/9-S1/2

[ 危险品运输编码 ]:
UN 1603 6.1/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
AF6000000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29159080

详细合成路线

溴乙酸乙酯上游产品

溴乙酸乙酯下游产品

1.先使溴与乙酸、乙酐在吡啶中反应制备溴乙酸，再由溴乙酸与乙醇在硫酸存在下反应生成溴乙酸乙酯。一般分两步制备。①溴乙酸的制备: 烧瓶中加入3L冰乙酸及100mL乙酸酐,再加入15g红磷或70g三溴化磷,搅拌下加热至100℃,开始从分液漏斗缓慢滴入300mL(900g,5.6mol)溴素,反应有诱发过程,不要加得太快,以免突发反应。待反应开始后(有HBr放出)保持90~100℃之间,再缓慢滴入2.0L溴素(总共2.3L,41mol),加完后继续搅拌、加热,使棕红色液体变为橘红色,此后,很少有放出。回收未反应的乙酸至蒸馏温度达140℃,约回收1L用于下次合成。②酯化: 将上述粗溴乙酸倾入于另一10L烧瓶中,加入5L工业乙醇及200mL硫酸,在沸水浴上回流12h,回收乙醇后用饱和食盐水洗三次,以无水硫酸钠干燥后分馏,收集154~158℃馏分,得2.4~2.6kg。

2.制法：

于装有分水器的反应瓶中，加入溴乙酸（2）220g（1.58mol），155mL无水乙醇（2.66mol），240mL甲苯和1mL浓硫酸，再加入沸石。加热回流，水、甲苯、乙醇在分水器中分层，甲苯流回反应瓶中，分出下层，约收集75mL。再加入乙醇20mL，继续回流反应0.5h。尽量蒸出乙醇和甲苯。将反应物倒入水中，静置分层。分出水层，再依次用5%的碳酸氢钠和水洗涤，无水硫酸钠干燥，分馏，收集164～168℃的馏分，得溴乙酸乙酯^①（1）205g，收率78%。注：①溴乙酸乙酯具有强烈的催泪作用，整个操作应在通风橱中进行。

[ 海关编码 ]: 2915900090

[ 中文概述 ]:
2915900090. 其他饱和无环一元羧酸及其酸酐（酰卤、过氧）化物、过氧酸及其卤化、硝化、磺化、亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Preoperative Detection and Intraoperative Visualization of Brain Tumors for More Precise Surgery: A New Dual-Modality MRI and NIR Nanoprobe.

Small 11 , 4517-25, (2015)

In clinical practice, it is difficult to identify tumor margins during brain surgery due to its inherent infiltrative character. Herein, a unique dual-modality nanoprobe (Gd-DOTA-Ag2S QDs, referred as...

Design and synthesis of a novel pre-column derivatization reagent with a 6-methoxy-4-quinolone moiety for fluorescence and tandem mass spectrometric detection and its application to chiral amino acid analysis.

J. Pharm. Biomed. Anal. 116 , 71-9, (2015)

A new pre-column derivatization reagent with a 6-methoxy-4-quinolone (6-MOQ) moiety for amino acid analysis, 2,5-dioxopyrrolidin-1-yl(2-(6-methoxy-4-oxoquinolin-1(4H)-yl)ethyl) carbonate (6-MOQ-EtOCOO...

Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.

J. Med. Chem. 53 , 5085-107, (2010)

更多文献

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：溴乙酸乙酯

---

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥155.0/100g ￥475.0/500g

联系人：刘佳

产品详情：溴乙酸乙酯

---

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥283.0/500g ￥50.0/25g ￥需询单/1g ￥93.0/100g

联系人：阿拉丁

产品详情：溴乙酸乙酯

---

查看所有供应商请点击：

溴乙酸乙酯供应商