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N-(4-磺酸丁基)-4-(4-(4-(二戊基氨基)苯基)丁二烯基)吡啶内盐

用途

RH 421是一种电压敏感的苯乙烯基染料,可以穿透脂质双层。RH 421是β-半乳糖苷酶的显色底物[1]。

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名称

[ CAS 号 ]:
107610-19-5

[ 中文名 ]:
N-(4-磺酸丁基)-4-(4-(4-(二戊基氨基)苯基)丁二烯基)吡啶内盐

[ 英文名 ]:
RH 421

[英文别名 ]:

MFCD00467839
Neurodye RH 421
RH 421

生物活性

[ 描述 ]:

RH 421是一种电压敏感的苯乙烯基染料,可以穿透脂质双层。RH 421是β-半乳糖苷酶的显色底物[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. D Y Malkov, et al. Fluorescent styryl dyes of the RH series affect a potential drop on the membrane/solution boundary. Biochim Biophys Acta. 1996 Jan 31;1278(2):197-204.

物理化学性质

[ 分子式 ]:
C₂₉H₄₂N₂O₃S

[ 分子量 ]:
498.72000

[ 精确质量 ]:
498.29200

[ PSA ]:
72.70000

[ LogP ]:
7.29370

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Membrane dipole modifiers modulate single-length nystatin channels via reducing elastic stress in the vicinity of the lipid mouth of a pore.

Biochim. Biophys. Acta 1848(1 Pt A) , 192-9, (2015)

The polyene antifungal antibiotic nystatin confers its biological activity by forming pores in the membranes of target cells. Exposure of only one side of the membrane to nystatin is more relevant tha...

[The effects of RH 421 on the activity of amphotericin B in cell and model membranes].

Tsitologiia 55(2) , 136-9, (2013)

The combined action of polyene macrolide antibiotic amphotericin B and styryl dye RH 421 in model lipid membranes and in yeast Saccharomyces cerevisiae has been studied. RH 421 insertion inti the ergo...

Probing amphotericin B single channel activity by membrane dipole modifiers.

PLoS ONE 7(1) , e30261, (2012)

The effects of dipole modifiers and their structural analogs on the single channel activity of amphotericin B in sterol-containing planar phosphocholine membranes are studied. It is shown that the add...

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