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间氯苯胺

间氯苯胺用途

【用途一】
用于有机合成
【用途二】
主要用于棉、麻、粘胶织物的染色和印花的显影剂，在医药上可制抗精神病药物盐酸氯丙嗪及奋乃静等
【用途三】
间氯苯胺是除草剂氯苯胺灵的中间体，也是医药利尿降压药双氢氯噻嗪的中间体，并可用于生产偶氮染料。
【用途四】
用作染料、农药、医药的中间体，其盐酸盐为冰染染料色基，主要用于棉、麻、粘胶织物的染色和印花的显色剂，在医药上可制氯丙嗪、磷酸氯喹等。也可制杀虫剂等。
【用途五】
有机合成。偶氮染料、颜料、药物、杀虫剂、农业化学品的中间体。
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间氯苯胺名称

[ CAS 号 ]:
108-42-9

[ 中文名 ]:
3-氯苯胺

[ 英文名 ]:
3-Chloroaniline

[中文别名 ]:

[英文别名 ]:

间氯苯胺物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
227.8±13.0 °C at 760 mmHg

[ 熔点 ]:
−11-−9 °C(lit.)

[ 分子式 ]:
C6H6ClN

[ 分子量 ]:
127.572

[ 闪点 ]:
123.9±0.0 °C

[ 精确质量 ]:
127.018875

[ PSA ]:
26.02000

[ LogP ]:
1.81

[ 外观性状 ]:
透明淡黄色至棕色液体

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.598

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类、食品添加剂分开存放

[ 水溶解性 ]:
6.8 g/L (20 ºC)

间氯苯胺MSDS

详细MSDS(安全技术说明书)

间氯苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BX0350000
CHEMICAL NAME :
Aniline, m-chloro-
CAS REGISTRY NUMBER :
108-42-9
LAST UPDATED :
199712
DATA ITEMS CITED :
25
MOLECULAR FORMULA :
C6-H6-Cl-N
MOLECULAR WEIGHT :
127.58
WISWESSER LINE NOTATION :
ZR CG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
256 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
150 ppm/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - corneal damage Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
334 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
550 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
223 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
125 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg/13W-I
TOXIC EFFECTS :
Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count Kidney, Ureter, Bladder - other changes in urine composition
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6125 mg/kg/35W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
14560 mg/kg/13W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight Blood - pigmented or nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
300 ug/L
REFERENCE :
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 39,359,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4029 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 851 (estimated) No. of Female Employees: 187 (estimated)
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间氯苯胺安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H311-H331-H373-H410

[ 警示性声明 ]:
P261-P273-P280-P301 + P310-P311-P501

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R23/24/25;R33;R50/53

[ 安全声明 (欧洲) ]:
S28-S36/37-S45-S60-S61-S28A

[ 危险品运输编码 ]:
UN 2019 6.1/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
BX0350000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2902909090

间氯苯胺合成路线

详细合成路线

间氯苯胺上下游产品

间氯苯胺上游产品

间氯苯胺下游产品

间氯苯胺制备

由间硝基氯苯在硫酸亚铁存在下用铁粉还原而得：也可以用硫化碱还原，还原反应后经中和，水蒸汽蒸馏，减压蒸馏得成品。工业品为微黄色至浅棕色油状液体，含量≥99%。原料消耗定额：间硝基氯苯1300kg/t、硫化碱960kg/t。
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间氯苯胺海关

[ 海关编码 ]: 2902909090

[ 中文概述 ]:
2902909090. 其他芳香烃. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:2.0%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量

[ Summary ]:
2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

间氯苯胺文献

cIEF for rapid pKa determination of small molecules: a proof of concept.

Eur. J. Pharm. Sci. 63 , 14-21, (2014)

A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) w...

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

J. Med. Chem. 48 , 3269-79, (2005)

Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm...

QSAR study on permeability of hydrophobic compounds with artificial membranes.

Bioorg. Med. Chem. 15 , 3756-67, (2007)

We previously reported a classical quantitative structure-activity relationship (QSAR) equation for permeability coefficients (P(app-pampa)) by parallel artificial membrane permeation assay (PAMPA) of...


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【间氯苯胺】化源网提供间氯苯胺CAS号108-42-9，间氯苯胺MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询间氯苯胺上化源网，专业又轻松。>>电脑版：间氯苯胺

标题：间氯苯胺_MSDS_用途_密度_间氯苯胺CAS号【108-42-9】_化源网 地址：https://m.chemsrc.com/mip/cas/108-42-9_952214.html