间氯苯胺
间氯苯胺用途
用于有机合成
【用途二】
主要用于棉、麻、粘胶织物的染色和印花的显影剂，在医药上可制抗精神病药物盐酸氯丙嗪及奋乃静等
【用途三】
间氯苯胺是除草剂氯苯胺灵的中间体，也是医药利尿降压药双氢氯噻嗪的中间体，并可用于生产偶氮染料。
【用途四】
用作染料、农药、医药的中间体，其盐酸盐为冰染染料色基，主要用于棉、麻、粘胶织物的染色和印花的显色剂，在医药上可制氯丙嗪、磷酸氯喹等。也可制杀虫剂等。
【用途五】
有机合成。偶氮染料、颜料、药物、杀虫剂、农业化学品的中间体。
间氯苯胺名称
[ CAS 号 ]:
108-42-9
[ 中文名 ]:
3-氯苯胺
[ 英文名 ]:
3-Chloroaniline
[中文别名 ]:
[英文别名 ]:
- Orange GC Base
- m-Aminochlorobenzene
- Benzenamine,3-chloro
- 1-Chloro-3-aminobenzene
- Aniline, m-chloro-
- 3-chlorobenzenamine
- m-chloraniline
- MFCD00007765
- m-Chloroaniline
- 1-Amino-3-chlorobenzene
间氯苯胺物理化学性质
[ 密度 ]:
1.2±0.1 g/cm3
[ 沸点 ]:
227.8±13.0 °C at 760 mmHg
[ 熔点 ]:
−11-−9 °C(lit.)
[ 分子式 ]:
C6H6ClN
[ 分子量 ]:
127.572
[ 闪点 ]:
123.9±0.0 °C
[ 精确质量 ]:
127.018875
[ PSA ]:
26.02000
[ LogP ]:
1.81
[ 外观性状 ]:
透明淡黄色至棕色液体
[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C
[ 折射率 ]:
1.598
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类、食品添加剂分开存放
[ 水溶解性 ]:
6.8 g/L (20 ºC)
间氯苯胺MSDS
间氯苯胺毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BX0350000
- CHEMICAL NAME :
- Aniline, m-chloro-
- CAS REGISTRY NUMBER :
- 108-42-9
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 25
- MOLECULAR FORMULA :
- C6-H6-Cl-N
- MOLECULAR WEIGHT :
- 127.58
- WISWESSER LINE NOTATION :
- ZR CG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 256 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 150 ppm/4H
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - corneal damage Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 334 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 550 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 223 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 125 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 gm/kg/13W-I
- TOXIC EFFECTS :
- Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count Kidney, Ureter, Bladder - other changes in urine composition
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6125 mg/kg/35W-I
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 14560 mg/kg/13W-I
- TOXIC EFFECTS :
- Endocrine - changes in spleen weight Blood - pigmented or nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 300 ug/L
- REFERENCE :
- BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 39,359,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4029 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 851 (estimated) No. of Female Employees: 187 (estimated)
间氯苯胺安全信息
[ 符号 ]:
GHS06, GHS08, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H301-H311-H331-H373-H410
[ 警示性声明 ]:
P261-P273-P280-P301 + P310-P311-P501
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
T:Toxic
[ 风险声明 (欧洲) ]:
R23/24/25;R33;R50/53
[ 安全声明 (欧洲) ]:
S28-S36/37-S45-S60-S61-S28A
[ 危险品运输编码 ]:
UN 2019 6.1/PG 2
[ WGK德国 ]:
2
[ RTECS号 ]:
BX0350000
[ 包装等级 ]:
II
[ 危险类别 ]:
6.1
[ 海关编码 ]:
2902909090
间氯苯胺合成路线
间氯苯胺上下游产品
间氯苯胺上游产品
间氯苯胺下游产品
间氯苯胺制备
由间硝基氯苯在硫酸亚铁存在下用铁粉还原而得：也可以用硫化碱还原，还原反应后经中和，水蒸汽蒸馏，减压蒸馏得成品。工业品为微黄色至浅棕色油状液体，含量≥99%。原料消耗定额：间硝基氯苯1300kg/t、硫化碱960kg/t。
间氯苯胺海关
[ 海关编码 ]: 2902909090
[ 中文概述 ]:
2902909090. 其他芳香烃. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:2.0%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量
[ Summary ]:
2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%
间氯苯胺文献
Eur. J. Pharm. Sci. 63 , 14-21, (2014)
A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) w...
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).J. Med. Chem. 48 , 3269-79, (2005)
Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm...
QSAR study on permeability of hydrophobic compounds with artificial membranes.Bioorg. Med. Chem. 15 , 3756-67, (2007)
We previously reported a classical quantitative structure-activity relationship (QSAR) equation for permeability coefficients (P(app-pampa)) by parallel artificial membrane permeation assay (PAMPA) of...
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产品详情：间氯苯胺
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区域：上海市奉贤区
价格：
￥265.0/500ml
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产品详情：间氯苯胺
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
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￥需询单/1mg
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产品详情：间氯苯胺
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￥320.0/500ml
￥6000.0/25kg
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相关化合物
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