氯苯_MSDS_用途_密度_氯苯CAS号【108-90-7】

用途一:用作染料、医药、农药、有机合成的中间体及溶剂。
用途二:用作分析试剂和有机溶剂，也用于有机合成。
用途三:氯苯用于生产农药品种三氯杀螨砜、滴滴涕等，还用于合成染料、医药以及其他有机化工产品，也用作乙基纤维素和许多树脂的溶剂以及生产多种中间体，例如对二氯苯、对氯苯磺酸、2，4-二硝基氯苯、邻硝基氯苯、对硝基氯苯、硝基酚等。
用途四:用作染料、医药、农药、有机合成的中间体。用于制造苯酚，硝基氯苯，苯胺以及杀虫剂DDT，还用于制取溶剂和橡胶助剂，油漆，快干墨水及干洗剂等。
用途五:溶剂，制造酚、苯胺、滴滴涕、染料、军用毒气气等，传热介质。
用途六:溶剂，制造酚、苯胺、滴滴涕、染料、军用毒气气等，传热介质。用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。

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[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
131.7±0.0 °C at 760 mmHg

[ 熔点 ]:
-45 °C

[ 分子式 ]:
C₆H₅Cl

[ 分子量 ]:
112.557

[ 闪点 ]:
23.9±0.0 °C

[ 精确质量 ]:
112.007980

[ LogP ]:
2.81

[ 外观性状 ]:
无色液体

[ 蒸汽密度 ]:
3.86 (vs air)

[ 蒸汽压 ]:
11.2±0.2 mmHg at 25°C

[ 折射率 ]:
1.527

[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开存放

[ 稳定性 ]:
Stable. Incompatible with oxidizing agents. Flammable. Attacks some types of plastics, rubber and coatings.

[ 水溶解性 ]:
0.4 g/L (20 ºC)

[ 凝固点 ]:
-45.6℃

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ0175000

CHEMICAL NAME :: Benzene, chloro-

CAS REGISTRY NUMBER :: 108-90-7

LAST UPDATED :: 199806

DATA ITEMS CITED :: 68

MOLECULAR FORMULA :: C6-H5-Cl

MOLECULAR WEIGHT :: 112.56

WISWESSER LINE NOTATION :: GR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1110 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2965 ppm

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1655 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 515 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >11 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 4100 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Liver - fatty liver degeneration Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 10 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14 gm/kg/14D-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32500 mg/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - peptidases Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27300 ug/kg/39W-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - eosinophilia Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 mg/m3/60D-C

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 ppm/7H/24W-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16250 mg/kg/13W-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, Bladder - other changes in urine composition Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 17712 mg/kg/93D-I

TOXIC EFFECTS :: Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 441 mg/kg/63W-I

TOXIC EFFECTS :: Gastrointestinal - gastritis Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 250 ppm/7H/24W-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 441 mg/kg/63W-I

TOXIC EFFECTS :: Gastrointestinal - gastritis Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 61800 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Blood - tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 75 ppm/6H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 210 ppm/6H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - hepatobiliary system

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 590 ppm/6H

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 10 ppm/6H

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 300 mg/L

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 236,933,1987 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 46 mg/m3 (10 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 75 ppm (350 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,49,1971 OSHA PEL (Gen Indu):8H TWA 75 ppm (350 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 75 ppm (350 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 75 ppm (350 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 75 ppm (350 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 1 ppm JAN 1993 OEL-AUSTRALIA:TWA 75 ppm (350 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 50 ppm (230 mg/m3) JAN 1993 OEL-BELGIUM:TWA 75 ppm (345 mg/m3) JAN 1993 OEL-DENMARK:TWA 50 ppm (230 mg/m3) JAN 1993 OEL-FINLAND:TWA 50 ppm (230 mg/m3);STEL 75 ppm (345 mg/m3) JAN 1993 OEL-FRANCE:TWA 75 ppm (350 mg/m3) JAN 1993 OEL-GERMANY:TWA 50 ppm (230 mg/m3) JAN 1993 OEL-INDIA:TWA 75 ppm (350 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 75 ppm (350 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 75 ppm (350 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 50 ppm (230 mg/m3);STEL 100 ppm (460 mg/m3) JAN 1993 OEL-TURKEY:TWA 75 ppm (350 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 50 ppm (230 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 18190 No. of Facilities: 1965 (estimated) No. of Industries: 36 No. of Occupations: 46 No. of Employees: 46734 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 18190 No. of Facilities: 912 (estimated) No. of Industries: 24 No. of Occupations: 35 No. of Employees: 18050 (estimated) No. of Female Employees: 3881 (estimated)

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[ 符号 ]:

GHS02, GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H226-H315-H332-H411

[ 警示性声明 ]:
P210-P261-P370 + P378

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R10;R20;R51/53

[ 安全声明 (欧洲) ]:
S24/25-S61-S36/37-S45

[ 危险品运输编码 ]:
UN 1134 3/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
CZ0175000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

[ 海关编码 ]:
2903919090

详细合成路线

氯苯上游产品

氯苯下游产品

1.氯苯是由苯直接氯化制得，这是英国于1909年首先进行工业化生产的方法，一直沿用至今。氯化工艺有气相法和液相法两种，气相法反应温度400～500℃，成本比液相法高，故已被淘汰；液相法又有间歇法和连续法两种。(1)间歇法把干燥的苯装入氯化反应器中，再加入相当于苯量1%的铁屑作催化剂，氯气的加入速度以能维持反应温度在40～60℃为宜，温度过高有利于多氯苯的生产。氯气鼓泡通入苯中至料液的相对密度达到1.280(15℃)。反应放出的氯化氢用苯或氯苯洗除有机雾滴，再用水吸收得到盐酸。氯化物料用10%的氢氧化钠中和，并经干燥、蒸馏，得下列馏分(以100%氯化料计)：苯和水(3%)，苯和氯苯(10%)，此二馏分返回系统；氯苯(75%)作为产品；氯苯和二氯苯(10%)，高沸物(2%)，此二馏分用于分离邻、对二氯苯。氯化产品的组成决定于氯化温度、氯化速率、氯化深度和采用的催化剂。一般氯化产品组成为氯苯80%，对二氯苯15%，邻二氯苯和多氯苯5%。(2)连续法氯化在苯的沸腾温度下进行，氯化器装有催化剂(铁屑或无水氯化铁)，反应热由苯和少量氯苯气化带出。经过干燥的苯经转子流量计计量后加入氯化器底部，与经计量的干燥氯气顺流进入氯化器反应。反应副产的HCl及部分苯和氯苯蒸气经石墨冷凝器冷凝，再经吸收塔用粗氯苯喷淋吸收。当吸收液含苯达32％～36％时，混入酸性氯化液去中和工序，而气体吸收成31%的副产盐酸。氯化器流出的酸性氯化液经水洗后，用碱液中和除去残余的酸及三氯化铁，再经盐干燥器，预热至一定温度后加入粗馏塔，从塔顶取出苯。塔釜的粗氯苯连续加入精馏塔，从塔顶得到氯苯，塔釜残液间断放出，回收其中的二氯苯。

2.以工业氯苯为原料，经精馏收集130～133℃间的馏分；精馏残液中主要为二氯苯的三种异构体和1,2,4-三氯苯，可用以提取这些物质。为制备色谱纯氯苯，可以氮气为载气，在装有DBS*固定相或SE30／红色硅藻土担体固定相柱的制备气相色谱仪上注入工业氯苯，经分离收集其主峰组分，然后装入玻璃安瓿瓶密封即可。DBS*：一种以阴离子表面活性剂为主的气相色谱固定相。

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[ 海关编码 ]: 2903919090

[ 中文概述 ]:
HS: 2903919090 氯苯退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 增值税率:17.0% 最低关税:5.5% 普通关税:30.0%

[ Summary ]:
HS: 2903919090 chlorobenzene Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:5.5% General tariff:30.0%

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