正溴丁烷

正溴丁烷用途

【用途一】
用作医药、染料、农药中间体
【用途二】
用作稀有元素萃取剂、烃化剂及有机合成原料，还可用作医药、染料和香料的原料
【用途三】
1-溴丁烷是杀菌剂二甲嘧酚和乙嘧酚的中间体。
【用途四】
用于合成麻醉药盐酸丁卡因，也用于生产染料和香料。
【用途五】
用于合成麻醉药盐酸丁卡因；也用于生产染料和香料。

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正溴丁烷名称

[ CAS 号 ]:
109-65-9

[ 中文名 ]:
正溴丁烷

[ 英文名 ]:
1-Bromobutane

[中文别名 ]:

[英文别名 ]:

1-bromo-n-butane
UNII-SAV6Y78U3D
n-Butyl bromide
1-Bromobutan
EINECS 203-691-9
N-Bromobutane
1-BROMO-BUTANE
n-Butylbiuret
MFCD00000260
n-butylbromide

正溴丁烷物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
101.6±3.0 °C at 760 mmHg

[ 熔点 ]:
-112 °C

[ 分子式 ]:
C₄H₉Br

[ 分子量 ]:
137.018

[ 闪点 ]:
23.9±0.0 °C

[ 精确质量 ]:
135.988754

[ LogP ]:
2.74

[ 外观性状 ]:
透明无色至略黄色液体

[ 蒸汽密度 ]:
4.7 (vs air)

[ 蒸汽压 ]:
40.3±0.2 mmHg at 25°C

[ 折射率 ]:
1.439

[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开存放

[ 稳定性 ]:
Stable. Flammable - note low flash point. Incompatible with strong oxidizing agents, strong bases.

[ 水溶解性 ]:
0.608 g/L (30 ºC)

正溴丁烷MSDS

正溴丁烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EJ6225000

CHEMICAL NAME :: Butane, 1-bromo-

CAS REGISTRY NUMBER :: 109-65-9

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C4-H9-Br

MOLECULAR WEIGHT :: 137.04

WISWESSER LINE NOTATION :: E4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPCEAO Journal fuer Praktische Chemie. (Johann Ambrosius Barth Verlag, Postfach 109, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1834- Volume(issue)/page/year: 320,133,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1424 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 20(12),52,1976

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 25800 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 18(4),55,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.3 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7278 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1822 (estimated) No. of Female Employees: 272 (estimated)

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正溴丁烷安全信息

[ 符号 ]:

GHS02, GHS07, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H315-H319-H335-H411

[ 警示性声明 ]:
P210-P261-P273-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R10;R36/37/38

[ 安全声明 (欧洲) ]:
S16-S26-S60-S37/39

[ 危险品运输编码 ]:
UN 1126 3/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
EJ6225000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2903399090

正溴丁烷合成路线

正溴丁烷上下游产品

正溴丁烷上游产品

正溴丁烷下游产品

正溴丁烷制备

1.由正丁醇在红磷存在下与溴作用而得；或由正丁醇在硫酸存在下与氢溴酸反应而得。正丁醇与氢溴酸混合，滴加入硫酸，加热回流反应1.5h，蒸馏得溴丁烷粗品，用水洗至pH为6-7，用无水氯化钙脱水即得。

2.制法：

于250mL反应瓶中加入水20mL，小心加入浓硫酸20mL。混合均匀后冷至室温。依次加入正丁醇（2）15g（0.2mol）、研细的溴化钠25g（0.24mol）。加入2粒沸石，装上回流冷凝器（顶部装一导气管至溴化氢吸收瓶）。加热回流反应1.5h，期间不断摇动反应瓶。冷后改为蒸馏装置，加热蒸馏，直至馏出液由浑浊变为澄清，得正溴丁烷粗品。将粗品水洗，分出有机层，以10mL浓硫酸洗涤，再依次用水、饱和碳酸氢钠、水洗涤，无水硫酸钠干燥，蒸馏，收集99～103℃的馏分，得正溴丁烷（1）16～18g，收率60%～65%。

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正溴丁烷海关

[ 海关编码 ]: 2903399090

[ 中文概述 ]:
2903399090. 其他无环烃的氟化、溴化或碘化衍生物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903399090. brominated,fluorinated or iodinated derivatives of acyclic hydrocarbons. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

正溴丁烷文献

Polymeric ionic liquid bucky gels as sorbent coatings for solid-phase microextraction

J. Chromatogr. A. 1344 , 15-22, (2014)

• Polymeric ionic liquid bucky gel sorbent coatings were developed for SPME. • Method involved on-fiber co-polymerization by thermal free-radical polymerization. • Sorbent coatings were used for the e...

A novel amino acid analysis method using derivatization of multiple functional groups followed by liquid chromatography/tandem mass spectrometry.

Analyst 140(6) , 1965-73, (2015)

We have developed a novel amino acid analysis method using derivatization of multiple functional groups (amino, carboxyl, and phenolic hydroxyl groups). The amino, carboxyl, and phenolic hydroxyl grou...

One-pot synthesis of 2,4,5-trisubstituted imidazoles using [BPy]H2PO4, an efficient and recyclable catalyst.

Prep Biochem Biotechnol. 43(2) , 189-96, (2013)

[BPy]H(2)PO(4) was easily prepared and used as an efficient and recyclable catalyst for the one-pot synthesis of 2,4,5-trisubstituted imidazoles under solvent-free conditions in good to excellent yiel...

更多文献

正溴丁烷

正溴丁烷用途

正溴丁烷名称

正溴丁烷物理化学性质

正溴丁烷MSDS

详细MSDS(安全技术说明书)

正溴丁烷毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

正溴丁烷安全信息

正溴丁烷合成路线

详细合成路线

正溴丁烷上下游产品

正溴丁烷上游产品

正溴丁烷下游产品

正溴丁烷制备

正溴丁烷海关

正溴丁烷文献

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