正溴丁烷

【用途一】
用作医药、染料、农药中间体
【用途二】
用作稀有元素萃取剂、烃化剂及有机合成原料，还可用作医药、染料和香料的原料
【用途三】
1-溴丁烷是杀菌剂二甲嘧酚和乙嘧酚的中间体。
【用途四】
用于合成麻醉药盐酸丁卡因，也用于生产染料和香料。
【用途五】
用于合成麻醉药盐酸丁卡因；也用于生产染料和香料。

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
101.6±3.0 °C at 760 mmHg

[ 熔点 ]:
-112 °C

[ 分子式 ]:
C₄H₉Br

[ 分子量 ]:
137.018

[ 闪点 ]:
23.9±0.0 °C

[ 精确质量 ]:
135.988754

[ LogP ]:
2.74

[ 外观性状 ]:
透明无色至略黄色液体

[ 蒸汽密度 ]:
4.7 (vs air)

[ 蒸汽压 ]:
40.3±0.2 mmHg at 25°C

[ 折射率 ]:
1.439

[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开存放

[ 稳定性 ]:
Stable. Flammable - note low flash point. Incompatible with strong oxidizing agents, strong bases.

[ 水溶解性 ]:
0.608 g/L (30 ºC)

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

EJ6225000

CHEMICAL NAME :

Butane, 1-bromo-

CAS REGISTRY NUMBER :

109-65-9

LAST UPDATED :

199710

DATA ITEMS CITED :

9

MOLECULAR FORMULA :

C4-H9-Br

MOLECULAR WEIGHT :

137.04

WISWESSER LINE NOTATION :

E4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

4450 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPCEAO Journal fuer Praktische Chemie. (Johann Ambrosius Barth Verlag, Postfach 109, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1834- Volume(issue)/page/year: 320,133,1978

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1424 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 20(12),52,1976

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

25800 mg/m3

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 18(4),55,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.3 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7278 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1822 (estimated) No. of Female Employees: 272 (estimated)

[ 符号 ]:

GHS02, GHS07, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H315-H319-H335-H411

[ 警示性声明 ]:
P210-P261-P273-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R10;R36/37/38

[ 安全声明 (欧洲) ]:
S16-S26-S60-S37/39

[ 危险品运输编码 ]:
UN 1126 3/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
EJ6225000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2903399090

详细合成路线

正溴丁烷上游产品

正溴丁烷下游产品

1.由正丁醇在红磷存在下与溴作用而得；或由正丁醇在硫酸存在下与氢溴酸反应而得。正丁醇与氢溴酸混合，滴加入硫酸，加热回流反应1.5h，蒸馏得溴丁烷粗品，用水洗至pH为6-7，用无水氯化钙脱水即得。

2.制法：

于250mL反应瓶中加入水20mL，小心加入浓硫酸20mL。混合均匀后冷至室温。依次加入正丁醇（2）15g（0.2mol）、研细的溴化钠25g（0.24mol）。加入2粒沸石，装上回流冷凝器（顶部装一导气管至溴化氢吸收瓶）。加热回流反应1.5h，期间不断摇动反应瓶。冷后改为蒸馏装置，加热蒸馏，直至馏出液由浑浊变为澄清，得正溴丁烷粗品。将粗品水洗，分出有机层，以10mL浓硫酸洗涤，再依次用水、饱和碳酸氢钠、水洗涤，无水硫酸钠干燥，蒸馏，收集99～103℃的馏分，得正溴丁烷（1）16～18g，收率60%～65%。

[ 海关编码 ]: 2903399090

[ 中文概述 ]:
2903399090. 其他无环烃的氟化、溴化或碘化衍生物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903399090. brominated,fluorinated or iodinated derivatives of acyclic hydrocarbons. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：溴代正丁烷

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥158.0/500g

联系人：刘佳

产品详情：溴代正丁烷

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥需询单/1mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：阿拉丁

产品详情：溴代正丁烷

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公司名：中山市迪欣化工有限公司

区域：中山市三角镇

价格：
￥80.0/250kg

联系人：陈雪萍

产品详情：溴乙烷

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