亚硝酸异戊酯

用于香料，药物，重氮化合物的合成。可作氧化剂，溶剂。亚硝酸异酯是一种药物，是作用最快的亚硝酸酯类短效血管扩张剂。还可作氢氰酸及其盐类中毒的解毒剂。

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
99.1±9.0 °C at 760 mmHg

[ 分子式 ]:
C₅H₁₁NO₂

[ 分子量 ]:
117.146

[ 闪点 ]:
10.0±0.0 °C

[ 精确质量 ]:
117.078979

[ PSA ]:
38.66000

[ LogP ]:
2.45

[ 外观性状 ]:
黄色液体

[ 蒸汽压 ]:
44.6±0.2 mmHg at 25°C

[ 折射率 ]:
1.425

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stability Unstable. Air and light sensitive. Flammable. Forms explosive mixtures with air or oxygen. Incompatible with oxidizing agents, reducing agents.

[ 水溶解性 ]:
<0.01 g/100 mL at 18 ºC

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

NT0187500

CHEMICAL NAME :

Isopentyl alcohol, nitrite

CAS REGISTRY NUMBER :

110-46-3

BEILSTEIN REFERENCE NO. :

0969510

LAST UPDATED :

199701

DATA ITEMS CITED :

12

MOLECULAR FORMULA :

C5-H11-N-O2

MOLECULAR WEIGHT :

117.17

WISWESSER LINE NOTATION :

ONO2Y

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

505 mg/kg

TOXIC EFFECTS :

Behavioral - general anesthetic

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

716 ppm/4H

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1430 ppm/30M

TOXIC EFFECTS :

Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

130 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

51 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

167 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold

MUTATION DATA

TYPE OF TEST :

Sister chromatid exchange

TEST SYSTEM :

Rodent - hamster Ovary

DOSE/DURATION :

16 mg/L

REFERENCE :

EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83996 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 33 (estimated)

[ 符号 ]:

GHS02, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302-H331

[ 警示性声明 ]:
P210-P261-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R11;R20/22

[ 安全声明 (欧洲) ]:
S16-S24-S46

[ 危险品运输编码 ]:
UN 1113 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
NT0187500

[ 包装等级 ]:
II

[ 危险类别 ]:
3

详细合成路线

亚硝酸异戊酯上游产品

亚硝酸异戊酯下游产品

1.由异戊醇与亚硝酸钠作用而得。根据实际生产情况可有不同的操作方法。1.反应在合成管内进行将亚硝酸钠水溶液、异戊醇、盐酸分别打入高位槽中。先将亚硝酸钠溶液和盐酸液以相同速度滴入合成管道中，当在管道内产生氯气泡后，从管道顶部慢慢滴加异戊醇，在管道合成即得粗品。经洗涤、干燥、分馏得成品。2.反应在反应罐中进行 将亚硝酸钠、异戊醇及水加入反应罐，搅拌，降温至5℃以下滴加盐酸。在5℃保温1h，静置后分去水层，酯层用水洗，再用碳酸钠溶液洗涤，再用水洗。分去水层后，用无水碳酸钠脱水，过滤。滤液蒸馏，收集97-99℃馏分，得亚硝酸异戊酯。

2.异戊醇在酸性环境下与亚硝酸钠作用，经洗涤、干燥、精馏得成品。

Poly-S-nitrosated human albumin enhances the antitumor and antimetastasis effect of bevacizumab, partly by inhibiting autophagy through the generation of nitric oxide.

Cancer Sci. 106(2) , 194-200, (2015)

Autophagy is one of the major causes of drug resistance. For example, the angiogenesis inhibitor bevacizumab shows only transient and short-term therapeutic effects, whereas long-term therapeutic bene...

Tuning of poly-S-nitrosated human serum albumin as superior antitumor nanomedicine.

J. Pharm. Sci. 103(7) , 2184-8, (2014)

Macromolecules have been developed as carriers of low-molecular-weight drugs in drug delivery systems (DDS) to improve their pharmacokinetic profile or to promote their uptake in tumor tissue via enha...

Molecular mechanisms of nitrovasodilator bioactivation.

Basic Res. Cardiol. 86 , 37-50, (1991)

All nitrovasodilators act intracellularly by a common molecular mechanism. This is characterized by the release of nitric oxide (NO). They are, thus, prodrugs or carriers of the active principle NO, r...

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价格：

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￥需询单/1g

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产品详情：Amyl nitrite

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￥需询单/1mg ￥需询单/1mg ￥需询单/1mg ￥需询单/1g

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