吡啶_MSDS_用途_密度_吡啶CAS号【110-86-1】

【用途一】
主要用作医药工业的原料，用作溶剂和酒精变性剂，也用于生产橡胶、油漆、树脂和缓蚀剂等
【用途二】
用作提取、分离吡啶及其同系物的原料
【用途三】
用作有机溶剂、分析试剂，也用于有机合成工业、色层分析等
【用途四】
GB 2760--1996规定为允许使用的食用香料。
【用途五】
吡啶是除草剂、杀虫剂、医药、橡胶助剂、纺织助剂的原料。
【用途六】
溶剂，有机合成。检定和测定锑、砷、铝、铋、镉、铈、氯酸盐、铬酸盐、氰酸盐、铬、钴、铜、氰化物、金、重铬酸盐、卤素、镧、铅、锂、锰、汞、锗、镍、高氯酸盐、过硫酸盐、铂、磷、铼、镨、硅、银、硫、铊、碲、硫氰酸盐、钍、硫代硫酸盐、钛、铀、钒、锌、锆。水分测定，菌种诱变剂。酰化反应的溶剂。催化剂。

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[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
115.3±0.0 °C at 760 mmHg

[ 熔点 ]:
-42 °C

[ 分子式 ]:
C₅H₅N

[ 分子量 ]:
79.100

[ 闪点 ]:
20.0±0.0 °C

[ 精确质量 ]:
79.042198

[ PSA ]:
12.89000

[ LogP ]:
0.73

[ 外观性状 ]:
透明干净的液体带有特有的气味

[ 蒸汽密度 ]:
2.72 (vs air)

[ 蒸汽压 ]:
22.8±0.2 mmHg at 25°C

[ 折射率 ]:
1.501

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Flammable. Incompatible with strong oxidizing agents, strong acids.

[ 水溶解性 ]:
Miscible

[ 凝固点 ]:
-42℃

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UR8400000

CHEMICAL NAME :: Pyridine

CAS REGISTRY NUMBER :: 110-86-1

LAST UPDATED :: 199806

DATA ITEMS CITED :: 64

MOLECULAR FORMULA :: C5-H5-N

MOLECULAR WEIGHT :: 79.11

WISWESSER LINE NOTATION :: T6NJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 891 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - coma

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28500 mg/m3/1H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 866 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 866 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 880 mg/kg

TOXIC EFFECTS :: Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1121 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands Liver - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - general anesthetic

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - tremor Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 870 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - tremor Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 870 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 10 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 mg/kg/14W-I

TOXIC EFFECTS :: Blood - change in clotting factors Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4200 mg/kg/28D-C

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in adrenal weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 mg/m3/24H/60D-C

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 494 mg/kg/5D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 163,23,1986 *** REVIEWS *** ACGIH TLV-TWA 16 mg/m3 (5 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1949- Volume(issue)/page/year: 4,1,1952 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 ppm (15 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,220,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (15 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (15 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (15 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (15 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 5 ppm (15 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 5 ppm (15 mg/m3) JAN 1993 OEL-BELGIUM:TWA 5 ppm (16 mg/m3) JAN 1993 OEL-DENMARK:TWA 5 ppm (15 mg/m3) JAN 1993 OEL-FINLAND:TWA 5 ppm (15 mg/m3);STEL 10 ppm (30 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (15 mg/m3);STEL 10 ppm (30 mg/m3) JAN 1993 OEL-GERMANY:TWA 5 ppm (15 mg/m3) JAN 1993 OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (15 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 5 mg/m3 JAN 1993 OEL-POLAND:TWA 5 mg/m3 JAN 1993 OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 OEL-SWEDEN:TWA 5 ppm (16 mg/m3);STEL 10 ppm (35 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (15 mg/m3);STEL 10 ppm (30 mg/m3) JAN 1993 OEL-TURKEY:TWA 5 ppm (15 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (15 mg/m3);STEL 10 ppm (30 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PYRIDINE-air:10H TWA 5 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 65080 No. of Facilities: 1103 (estimated) No. of Industries: 22 No. of Occupations: 18 No. of Employees: 29286 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 65080 No. of Facilities: 1558 (estimated) No. of Industries: 32 No. of Occupations: 42 No. of Employees: 42908 (estimated) No. of Female Employees: 10568 (estimated)

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[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302 + H312 + H332-H315-H319

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable;Xn:Harmful;

[ 风险声明 (欧洲) ]:
R11;R20/21/22

[ 安全声明 (欧洲) ]:
S36/37/39-S38-S45-S61-S28A-S26-S28-S24/25-S22-S36/37-S16-S7

[ 危险品运输编码 ]:
UN 1282 3/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
UR8400000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2933990090

吡啶上游产品

吡啶下游产品

1.将乙醛（1.648mol）、37%甲醛（1.665mol）和氨（3.096mol）的混合物，于432℃反应，催化剂为SiO2-Al2O3-Bi2O3，吡啶收率为48.4%。同时还生成β-甲基吡啶，改变操作条件，可调节吡啶和甲基吡啶和甲基吡啶的收率。此外，1,5-戊二胺盐酸盐，经加热环合，在Pt催化剂存在下脱氢也可制得吡啶。

精制方法：主要杂质是水和它的同系物。水可用氢氧化钾、氢氧化钠、氧化钡、氧化钙或金属钠回流后蒸馏除去。也可用4A型分子筛、氢化钙、氢化铝锂脱水。工业上常用与苯或甲苯组成的共沸混合物进行共沸蒸馏脱水。同系物的分离除用分馏法外，可用与氯化锌或氯化汞形成加成化合物的方法精制。例如，将424g氯化锌和365mL水配成的溶液与173mL的浓盐酸和345mL　95.6%乙醇混合，加入500mL新蒸馏的吡啶。经过一段时间后，组成为2C5H5N·ZnCl2的产物从溶液中结晶析出。过滤后用无水乙醇重结晶两次。将此晶体用浓氢氧化钠溶液分解（每100g晶体用氢氧化钠26.7g）。过滤，将所得游离吡啶用固体氢氧化钾或氧化钡干燥后分馏。为分离吡啶的同系物，也可以在搅拌下将吡啶加入草酸的丙酮溶液中。吡啶形成草酸盐沉淀，过滤后用冷的丙酮洗涤，再加碱使吡啶再生。吡啶中所含的非碱性杂质，可以在酸性溶液中用水蒸气蒸馏除去。此外，尚有用氧化剂处理的精制方法。例如将135mL吡啶，2.5L水，90g高锰酸钾于100℃搅拌2小时，放置15小时后过滤，滤液中加入约500g氢氧化钠使吡啶分离。倾出吡啶，用氧化钙回流3小时后蒸馏。

2.对焦化过程中生成的焦炉气中的吡啶碱进行回收处理得到吡啶。或者由乙醛、甲醛和氨的混合物反应可得吡啶。也可以将1,5-戊二胺盐酸盐加热环合，在铂催化剂存在下脱氢制得吡啶。

3. 取工业吡啶为原料，通过常压精馏收集其114～116℃馏份，装入棕色玻璃瓶中即为成品。为制备色谱纯吡啶，可以氮气为载气，在制备气相色谱仪上注入工业吡啶，通过分离收集其主峰组分，然后装入玻璃安瓿瓶中密封即可。

4.以醛或酮与氨为原料的合成法　最普通的吡啶类的工业合成法是用价廉易得的各种醛或酮和氨反应，得到各种各样的吡啶。饱和脂肪醛和氨的反应，3mol饱和脂肪醛和1mol氨形成吡啶环。理论上，氨的用量是醛或酮的1／2或1／3，但为防止收率及催化剂活性下降，通常过量0.9～9倍。反应条件是，混合气空速为500～1000／h，反应温度为400～500℃。通常用氧化铝 氧化硅系的催化剂，为提高收率、延长催化剂的寿命及便于再生而配入各种金属。反应式如下：

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[ 海关编码 ]: 2933310010

[ 中文概述 ]:
2933310010 吡啶。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最低关税:6.0%。普通关税:20.0%

[ Summary ]:
2933310010 pyridine。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.0%。general tariff:20.0%

Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography.

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This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u...

The identification of a novel SIRT6 modulator from Trigonella foenum-graecum using ligand fishing with protein coated magnetic beads.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 968 , 105-11, (2014)

SIRT6 is a histone deacetylase that has been proposed as a potential therapeutic target for metabolic disorders and the prevention of age-associated diseases. Thus the identification of compounds that...

Discovery of optimal zeolites for challenging separations and chemical transformations using predictive materials modeling.

Nat. Commun. 6 , 5912, (2015)

Zeolites play numerous important roles in modern petroleum refineries and have the potential to advance the production of fuels and chemical feedstocks from renewable resources. The performance of a z...

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥818.0/500ml ￥298.0/100ml ￥318.0/500ml ￥188.0/100ml

联系人：刘佳

产品详情：吡啶

公司名：盘锦研峰科技有限公司

区域：盘锦市盘锦市双台子区

价格：
￥70.0/100ton

联系人：王迎

产品详情：吡啶

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥需询单/1mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：阿拉丁李高志

产品详情：吡啶

公司名：济南创世化工有限公司

区域：济南市天桥区

价格：
￥需询单/200kg

联系人：严玲玲

产品详情：吡啶

公司名：济南世纪通达化工有限公司

区域：济南市天桥区

价格：
￥38000.0/1ton ￥75000.0/2ton

联系人：王经理

产品详情：吡啶

查看所有供应商请点击：

吡啶供应商

吡啶有什么危害？女生能碰吡啶吗？

2019-06-10 13:10:19

经常看到有人问吡啶对女孩子有什么危害？男生能碰吡啶吗？下面让小编来为大家回答。吡啶，有机化合物，是含有一个氮杂原子的六元杂环化合物。可以看做苯分子中的一个（CH）被N取代的化合物，故又称氮苯，无色或微黄色液体，有恶臭。吡啶及其同系物存在于骨焦油、煤焦油、煤气、页岩油、石油中。吡啶在工业上可用作变性...

吡啶类农药是什么，有哪些品种？

2019-06-10 17:49:50

吡啶及其衍生物比苯稳定，其反应性与硝基苯类似。典型的芳香族亲电取代反应发生在3、5位上，但反应性比苯低，一般不易发生硝化、卤化、磺化等反应。吡啶是一个弱的三级胺，在乙醇溶液内，能与多种酸(如苦味酸或高氯酸等)形成不溶于水的盐。吡啶类农药被称为第四代农药，具有高效、低毒的特点，与人和生物具有良好的环...

吡啶

吡啶用途

吡啶名称

吡啶物理化学性质

吡啶MSDS

详细MSDS(安全技术说明书)

吡啶毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

吡啶安全信息

吡啶上下游产品

吡啶上游产品

吡啶下游产品

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