匹哌环素

匹哌环素用途

Pipacycline is a tetracycline antibiotic derivative. It inhibits the formation of penicillinase, the enzyme that inactivates penicillin in bacteria. It decreases oxygen uptake and inhibits growth of penicillin-resistant penicillinase-producing S. aureus.

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匹哌环素名称

[ CAS 号 ]:
1110-80-1

[ 中文名 ]:
匹哌环素

[ 英文名 ]:
Mepicycline

[英文别名 ]:

Pipacicline
Tetrasolvina
EINECS 214-176-3
Hydroxyethyl-piperazinomethyl-tetracyclin
penimepicycline
Mepicycline
Sieromicin
Pipacyclinum

匹哌环素物理化学性质

[ 密度 ]:
1.55g/cm3

[ 沸点 ]:
810.7ºC at 760mmHg

[ 分子式 ]:
C₂₉H₃₈N₄O₉

[ 分子量 ]:
586.63300

[ 闪点 ]:
444.1ºC

[ 精确质量 ]:
586.26400

[ PSA ]:
194.34000

[ 蒸汽压 ]:
8.99E-28mmHg at 25°C

[ 折射率 ]:
1.717

匹哌环素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QI8575000

CHEMICAL NAME :: 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6, 10,12,12a- pentahydroxy-N-((4-(2-hydroxyethyl)-1-piperazinyl)met hyl)-6-methyl-1,11-di oxo-

CAS REGISTRY NUMBER :: 1110-80-1

LAST UPDATED :: 198502

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C29-H38-N4-O9

MOLECULAR WEIGHT :: 586.71

WISWESSER LINE NOTATION :: L E6 C666 BV FV CU GUTTT&J DQ EQ HQ IN1&1 MQ M1 RQ GVM1- AT6N DNTJ D2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 188 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GMITAB Gazzetta Medica Italiana. (Turin, Italy) V.95-142, 1936-83. Volume(issue)/page/year: 131,1,1972