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S-(+)-盐酸尼古地平

S-(+)-盐酸尼古地平名称

[ CAS 号 ]:
113165-32-5

[ 中文名 ]:
S-(+)-尼古地平盐酸

[ 英文名 ]:
S(+)-Niguldipine hydrochloride

[中文别名 ]:

尼古地平

[英文别名 ]:

MFCD00873564

S-(+)-盐酸尼古地平物理化学性质

[ 密度 ]:
1.205g/cm3

[ 沸点 ]:
729.5ºC at 760 mmHg

[ 分子式 ]:
C₃₆H₃₉N₃O₆

[ 分子量 ]:
609.71100

[ 闪点 ]:
395ºC

[ 精确质量 ]:
609.28400

[ PSA ]:
113.69000

[ LogP ]:
6.80790

[ 蒸汽压 ]:
3.9E-21mmHg at 25°C

[ 折射率 ]:
1.589

S-(+)-盐酸尼古地平MSDS

详细MSDS(安全技术说明书)

S-(+)-盐酸尼古地平安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

S-(+)-盐酸尼古地平文献

(+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha 1-adrenoceptors.

Eur. J. Pharmacol. 172 , 131-145, (1989)

The enantiomers of the 1,4-dihydropyridine (DHP) niguldipine (3-methyl-5-[3-(4,4-diphenyl-1-piperidinyl)-propyl]- 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate- hydrochloride) ...

Pharmacological modulation of calcium and potassium channels in isolated vascular smooth muscle cells.

Arzneimittelforschung 39 , 120-126, (1989)

Calcium antagonists relax vascular smooth muscle cells (VSM) by decreasing Ca-influx and intracellular Ca-load. In isolated VSM, Ca-influx was measured as Ca-current by the voltage clamp technique app...

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