Levitide

Levitide用途

莱维特是一种神经激素样肽,可以从南非非洲爪蟾的皮肤分泌物中分离出来。利未肽来自于前磷脂,长88个残基,包含C端的利未肽肽(Glu-Gly-Met-Ile-Gly-Thr-Thr-Ser-Lys-Arg-Ile-Lys-Gln-NH2)和N端的推定信号序列[1]。

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Levitide名称

[ CAS 号 ]:
114281-19-5

[ 英文名 ]:
Levitide

[英文别名 ]:

PYR-GMIGTLTSKRIKQ-NH2

Levitide生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体外研究]

前磷脂,也被称为悬浮蛋白前体,显示出与异种蛋白酶前体惊人的核苷酸和氨基酸序列同源性。Xenopsin是一种八肽,也编码一种25个残基的两亲性肽,通过在单个精氨酸残基处加工释放[1]。

[参考文献]

[1]. Poulter L, et al. Levitide, a neurohormone-like peptide from the skin of Xenopus laevis. Peptide and peptide precursor cDNA sequences. J Biol Chem. 1988 Mar 5;263(7):3279-83.

Levitide物理化学性质

[ 密度 ]:
1.44 g/cm3

[ 分子式 ]:
C₆₆H₁₁₉N₂₁O₁₉S

[ 分子量 ]:
1542.85000

[ 精确质量 ]:
1541.87000

[ PSA ]:
693.51000

[ LogP ]:
1.15020

[ 折射率 ]:
1.64

Levitide安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

Levitide文献

Levitide, a neurohormone-like peptide from the skin of Xenopus laevis. Peptide and peptide precursor cDNA sequences.

J. Biol. Chem. 263 , 3279, (1988)

A novel peptide, levitide, less than Glu-Gly-Met-Ile-Gly-Thr-Leu-Thr-Ser-Lys-Arg-Ile-Lys-Gln-NH2 has been isolated from skin secretions of the South African frog Xenopus laevis and sequenced by fast a...

The genes for the frog skin peptides GLa, xenopsin, levitide and caerulein contain a homologous export exon encoding a signal sequence and part of an amphiphilic peptide.

Eur. J. Biochem. 179(2) , 281-5, (1989)

From genomic libraries of Xenopus laevis, parts of the genes coding for the precursors of the skin peptides GLa (peptide with amino-terminal glycine and carboxy-terminal leucinamide), xenopsin and lev...

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