6-[荧光素-5 (6)-甲酰胺基] 己酸 N -羟基琥珀酰亚胺酯

用途

6- [荧光素-5(6)-羧酰胺基]己酸N-羟基琥珀酰亚胺酯（FHS）用作将荧光团6- [荧光素-5（6）-羧酰胺基]己酸缀合到分子上的试剂。6- [荧光素-5(6)-羧酰胺基]己酸用作基于荧光素的蛋白质荧光标记，可在淬灭实验等应用中进行分析。己酸间隔基使反应性基团更易与生物聚合物上的亲核试剂接触

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名称

[ CAS 号 ]:
114616-31-8

[ 中文名 ]:
6-[荧光素-5(6)-甲酰氨基]-己酸-N-羟基琥珀酰亚胺酯

[ 英文名 ]:
6-[Fluorescein-5(6)-carboxamido]hexanoic acid N-hydroxysuccinimide ester

[英文别名 ]:

生物活性

[ 描述 ]:

5(6)-SFX,SE(化合物SFX-SE)是一种荧光染料,用于标记伯胺和新生蛋白质[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Kenneth J, et al. Methods For The Detection, Analysis And Isolation Of Nascent Proteins. US20110250609.

[2]. Ito K, et al. Artificial human Met agonists based on macrocycle scaffolds. Nat Commun. 2015 Mar 11;6:6373.

物理化学性质

[ 分子式 ]:
C₃₁H₂₆N₂O₁₀

[ 分子量 ]:
586.54600

[ 精确质量 ]:
586.15900

[ PSA ]:
168.77000

[ LogP ]:
3.89200

[ 外观性状 ]:
固体

[ 储存条件 ]:
20°C

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Defects in calcium homeostasis and mitochondria can be reversed in Pompe disease.

Autophagy 11(2) , 385-402, (2015)

Mitochondria-induced oxidative stress and flawed autophagy are common features of neurodegenerative and lysosomal storage diseases (LSDs). Although defective autophagy is particularly prominent in Pom...

Liver cell uptake and degradation of soluble immunoglobulin G immune complexes in vivo and in vitro in rats.

Hepatology 24 , 169-175, (1996)

Immune complexes were formed between dinitrophenylated human serum albumin (DNP-HSA) and polyclonal rabbit immunoglobulin G (IgG) anti-DNP antibodies at antibody excess. The antigen was labelled with ...

Dynamics at Lys-553 of the acto-myosin interface in the weakly and strongly bound states.

Biophys. J. 78 , 1441-1448, (2000)

Lys-553 of skeletal muscle myosin subfragment 1 (S1) was specifically labeled with the fluorescent probe FHS (6-[fluorescein-5(and 6)-carboxamido]hexanoic acid succinimidyl ester) and fluorescence que...

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