吡咯戊酮

吡咯戊酮名称

[ CAS 号 ]:
1147-62-2

[ 中文名 ]:
吡咯戊酮

[ 英文名 ]:
Pyrovalerone hydrochloride solution

[中文别名 ]:

[英文别名 ]:

EINECS 214-556-9
Pyrovalerone hydrochloride

吡咯戊酮物理化学性质

[ 沸点 ]:
362.4ºC at 760mmHg

[ 熔点 ]:
171-174°C

[ 分子式 ]:
C₁₆H₂₄ClNO

[ 分子量 ]:
281.821

[ 闪点 ]:
127.3ºC

[ 精确质量 ]:
281.154633

[ PSA ]:
20.31000

[ LogP ]:
4.18210

[ 蒸汽压 ]:
1.93E-05mmHg at 25°C

[ 储存条件 ]:
Controlled Substance, -20°C Freezer, Under Inert Atmosphere

吡咯戊酮MSDS

详细MSDS(安全技术说明书)

吡咯戊酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YV9100000

CHEMICAL NAME :: Valerophenone, 4'-methyl-2-(1-pyrrolidinyl)-, hydrochloride

CAS REGISTRY NUMBER :: 1147-62-2

LAST UPDATED :: 199706

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H23-N-O.Cl-H

MOLECULAR WEIGHT :: 281.86

WISWESSER LINE NOTATION :: T5NTJ AY3&VR D1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 620 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,294,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 47 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,294,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,871,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 261 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,294,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 43 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,294,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,294,1972

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吡咯戊酮安全信息

[ 符号 ]:

GHS05, GHS07, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H318-H411

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn,T,F

[ 风险声明 (欧洲) ]:
22-41-52-39/23/24/25-23/24/25-11

[ 安全声明 (欧洲) ]:
26-39-45-36/37-16-7

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ RTECS号 ]:
YV9100000

[ 海关编码 ]:
2933910022

吡咯戊酮海关

[ 海关编码 ]: 2933910022

吡咯戊酮文献

[Issues on the use of ethnobotanicals].

Rev. Med. Chir. Soc. Med. Nat. Iasi. 115(4) , 1069-72, (2011)

To identify the risk factors for the use of ethnobotanicals and the people at risk to becoming users.This questionnaire basez objective population study included 89 subjects aged 14 to 42 years.19.10%...

1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors.

J. Med. Chem. 49(4) , 1420-32, (2006)

Dopamine, serotonin, and norepinephrine are essential for neurotransmission in the mammalian system. These three neurotransmitters have been the focus of considerable research because the modulation o...

Toxicological determination and in vitro metabolism of the designer drug methylenedioxypyrovalerone (MDPV) by gas chromatography/mass spectrometry and liquid chromatography/quadrupole time-of-flight mass spectrometry.

Rapid Commun. Mass Spectrom. 24(18) , 2706-14, (2010)

A method for the toxicological screening of the new designer drug methylenedioxypyrovalerone (MDPV) is described; with an emphasis on its application for anti-doping analysis. The metabolism of MDPV w...

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