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2,2-二乙基-1,3-丙二醇

2,2-二乙基-1,3-丙二醇用途

普伦德罗是一种有效的中枢神经系统抑制剂。普伦德罗具有抗惊厥活性[1]。

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2,2-二乙基-1,3-丙二醇名称

[ CAS 号 ]:
115-76-4

[ 中文名 ]:
2,2-乙基-1,3丙二醇

[ 英文名 ]:
Prenderol

[中文别名 ]:

[英文别名 ]:

2,2-DIETHYL-1,3-PROPANEDIOL
2,2-diethylpropane-1,3-diol
2,2-Dihydroxy-2,2-diethylpropane
3,3-Bis(hydroxymethyl)pentane
EINECS 204-103-3
2,2-Diethyl-2,2-dihydroxypropane
MFCD00004695

2,2-二乙基-1,3-丙二醇生物活性

[ 描述 ]:

普伦德罗是一种有效的中枢神经系统抑制剂。普伦德罗具有抗惊厥活性[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Slater, I. H., et al. 2,2-Diethyl-1,4-butanediol, a convulsant homolog of the depressant, 2,2-diethyl-1,3-propanediol.

2,2-二乙基-1,3-丙二醇物理化学性质

[ 密度 ]:
0.95g/mLat 25°C (lit.)

[ 沸点 ]:
160 °C (50 mmHg)

[ 熔点 ]:
59-61 °C(lit.)

[ 分子式 ]:
C₇H₁₆O₂

[ 分子量 ]:
132.20100

[ 闪点 ]:
102 °C

[ 精确质量 ]:
132.11500

[ PSA ]:
40.46000

[ LogP ]:
0.77740

[ 外观性状 ]:
白色至略黄色结晶粉末

[ 蒸汽压 ]:
0.00657mmHg at 25°C

[ 折射率 ]:
1.451

[ 储存条件 ]:
室温

2,2-二乙基-1,3-丙二醇MSDS

2,2-二乙基-1,3-丙二醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TY5250000

CHEMICAL NAME :: 1,3-Propanediol, 2,2-diethyl-

CAS REGISTRY NUMBER :: 115-76-4

BEILSTEIN REFERENCE NO. :: 1697711

LAST UPDATED :: 199806

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C7-H16-O2

MOLECULAR WEIGHT :: 132.23

WISWESSER LINE NOTATION :: Q1X2&2&1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 2/21/1958 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 2/21/1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 100,27,1950

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 635 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 100,27,1950

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1550 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 100,27,1950

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1220 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 100,27,1950

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1170 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 100,27,1950

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4240 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 10,61,1954

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2,2-二乙基-1,3-丙二醇安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319

[ 警示性声明 ]:
P301 + P312 + P330-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
TY5250000

[ 海关编码 ]:
2905399090

2,2-二乙基-1,3-丙二醇合成路线

2,2-二乙基-1,3-丙二醇上下游产品

2,2-二乙基-1,3-丙二醇上游产品

2,2-二乙基-1,3-丙二醇下游产品

2,2-二乙基-1,3-丙二醇海关

[ 海关编码 ]: 2905399090

[ 中文概述 ]:
2905399090 其他二元醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2905399090 other diols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%