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布洛芬酰基葡糖苷酸

布洛芬酰基葡糖苷酸名称

[ CAS 号 ]:
115075-59-7

[ 中文名 ]:
布洛芬酰基葡糖苷酸

[ 英文名 ]:
Ibuprofen Acyl-b-D-glucuronide

[英文别名 ]:

ibuprofen acyl glucuronide
Ibuprofen Acyl--D-glucuronide
Ibuprofen Acyl-Beta-D-glucuronide
Ibuprofen glucuronide

布洛芬酰基葡糖苷酸物理化学性质

[ 密度 ]:
1.34g/cm3

[ 沸点 ]:
567.3ºC at 760 mmHg

[ 熔点 ]:
26-28ºC

[ 分子式 ]:
C₁₉H₂₆O₈

[ 分子量 ]:
382.40500

[ 闪点 ]:
198.3ºC

[ 精确质量 ]:
382.16300

[ PSA ]:
133.52000

[ LogP ]:
0.42400

[ 蒸汽压 ]:
1.05E-13mmHg at 25°C

[ 折射率 ]:
1.581

[ 储存条件 ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

[ 稳定性 ]:
Hygroscopic, Not stable in aqueous solutions.

布洛芬酰基葡糖苷酸MSDS

详细MSDS(安全技术说明书)

布洛芬酰基葡糖苷酸安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

布洛芬酰基葡糖苷酸文献

Direct determination of ibuprofen and ibuprofen acyl glucuronide in plasma by high-performance liquid chromatography using solid-phase extraction.

J. Chromatogr. A. 614(1) , 109-16, (1993)

A method for the simultaneous determination of ibuprofen and its labile, reactive metabolite, ibuprofen acyl glucuronide, in plasma is described. Reversed-phase high-performance liquid chromatography ...

Disposition and reactivity of ibuprofen and ibufenac acyl glucuronides in vivo in the rhesus monkey and in vitro with human serum albumin.

Drug Metab. Dispos. 23(5) , 566-72, (1995)

The disposition of ibuprofen and ibufenac, an analog of ibuprofen with a history of severe adverse reactions, was investigated in Rhesus monkeys after oral administration. Plasma concentrations of the...

Stereoselective Inhibition of Methotrexate Excretion by Glucuronides of Nonsteroidal Anti-inflammatory Drugs via Multidrug Resistance Proteins 2 and 4.

J. Pharmacol. Exp. Ther. 356 , 366-74, (2016)

Combined administration of methotrexate (MTX) and nonsteroidal anti-inflammatory drugs (NSAIDs) can result in a decreased systemic clearance of MTX. To date, inhibition of renal uptake via organic ani...

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