ipazilide fumarate
ipazilide fumarate名称
[ CAS 号 ]:
115436-74-3
[ 英文名 ]:
ipazilide fumarate
[英文别名 ]:
- IPAZILIDE FUMARATE
- Ipazilide fumarate (USAN)
ipazilide fumarate物理化学性质
[ 沸点 ]:
569.7ºC at 760mmHg
[ 分子式 ]:
C28H34N4O5
[ 分子量 ]:
506.59300
[ 闪点 ]:
298.4ºC
[ 精确质量 ]:
506.25300
[ PSA ]:
128.25000
[ LogP ]:
4.61730
[ 蒸汽压 ]:
5.4E-13mmHg at 25°C
ipazilide fumarate毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UQ4903600
- CAS REGISTRY NUMBER :
- 115436-74-3
- LAST UPDATED :
- 199403
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C24-H30-N4-O.C4-H4-O4
- MOLECULAR WEIGHT :
- 506.66
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Cardiac - pulse rate increase, without fall in BP
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,581,1992 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 29200 mg/kg/1Y-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Endocrine - changes in thyroid weight Blood - changes in leukocyte (WBC) count
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 20,147,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9280 mg/kg/29D-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - proteinuria Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,581,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 870 mg/kg/29D-I
- TOXIC EFFECTS :
- Cardiac - pulse rate increase, without fall in BP Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,581,1992
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