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N-苄氧羰基-L-苯丙氨酸

N-苄氧羰基-L-苯丙氨酸用途

Z-Phe-OH是苯丙氨酸衍生物[1]。

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N-苄氧羰基-L-苯丙氨酸名称

[ CAS 号 ]:
1161-13-3

[ 中文名 ]:
N-苄氧羰基-L-苯丙氨酸

[ 英文名 ]:
N-Cbz-L-Phenylalanine

[中文别名 ]:

[英文别名 ]:

L-Phenylalanine, N-[(phenylmethoxy)carbonyl]-
N-Cbz-L-phenylalanine
N-Benzyloxycarbonyl-L-phnylalanine
MFCD00020418
Phenylalanine, N-[(phenylmethoxy)carbonyl]-
Z-L-Phenylalanine
EINECS 214-599-3
N-[(Benzyloxy)carbonyl]phenylalanine
N-carbobenzyloxy-dl-phenylalanine
N-Carbobenzyloxy-L-phenylalanine

N-苄氧羰基-L-苯丙氨酸生物活性

[ 描述 ]:

Z-Phe-OH是苯丙氨酸衍生物[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

氨基酸和氨基酸衍生物已被商业化用作能量补充剂。它们影响合成代谢激素的分泌、运动期间的燃料供应、压力相关任务期间的精神表现,并防止运动引起的肌肉损伤。它们被认为是有益的能生膳食物质[1]。

[参考文献]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-883.

N-苄氧羰基-L-苯丙氨酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
511.5±50.0 °C at 760 mmHg

[ 熔点 ]:
85-87 °C(lit.)

[ 分子式 ]:
C₁₇H₁₇NO₄

[ 分子量 ]:
299.321

[ 闪点 ]:
263.1±30.1 °C

[ 精确质量 ]:
299.115753

[ PSA ]:
75.63000

[ LogP ]:
3.58

[ 外观性状 ]:
白色非晶形的粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.591

[ 储存条件 ]:
库房低温通风干燥

N-苄氧羰基-L-苯丙氨酸MSDS

详细MSDS(安全技术说明书)

N-苄氧羰基-L-苯丙氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY4343000

CHEMICAL NAME :: Alanine, N-carboxy-3-phenyl-, N-benzyl ester, L-

CAS REGISTRY NUMBER :: 1161-13-3

LAST UPDATED :: 199206

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H17-N-O4

MOLECULAR WEIGHT :: 299.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 251 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,1726,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravaginal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 280 mg/kg

SEX/DURATION :: female 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 280 mg/kg

SEX/DURATION :: female 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979

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N-苄氧羰基-L-苯丙氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R62

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AY4343000

[ 海关编码 ]:
2924299090

N-苄氧羰基-L-苯丙氨酸上下游产品

N-苄氧羰基-L-苯丙氨酸上游产品

N-苄氧羰基-L-苯丙氨酸下游产品

N-苄氧羰基-L-苯丙氨酸海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-苄氧羰基-L-苯丙氨酸文献

Effects of metalloendoproteinase inhibitors on secretion and intracellular free calcium in bovine adrenal chromaffin cells.

Biochim. Biophys. Acta 889(1) , 1-5, (1986)

The possible role of metalloendoproteinase in stimulus-secretion coupling in adrenal chromaffin cells was examined using the metalloendoproteinase inhibitors 1,10-phenanthroline and carbobenzoxy-Gly-P...

Mechanism of the binding of Z-L-tryptophan and Z-L-phenylalanine to thermolysin and stromelysin-1 in aqueous solutions.

Biochim. Biophys. Acta 1824(2) , 303-10, (2012)

The chemical shift of the carboxylate carbon of Z-tryptophan is increased from 179.85 to 182.82 ppm and 182.87 ppm on binding to thermolysin and stromelysin-1 respectively. The chemical shift of Z-phe...

Modification of a zinc proteinase from Bacillus mesentericus strain 76 by diethylpyrocarbonate.

Int. J. Pept. Protein Res. 37(4) , 325-30, (1991)

Diethylpyrocarbonate (DEPC) inactivated the neutral zinc proteinase from Bacillus mesentericus strain 76/Bacillus subtilis (MCP 76) by ethoxycarbonylation completely. Exposure of the enzyme to DEPC to...

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