灯盏花素

灯盏花素用途

灯盏花素是灯盏花素的一种黄酮类粗提物,含有灯盏花素85%以上的有效成分。灯盏花素具有广泛的心血管药理活性,如增加血流量、改善微循环、扩张血管、降低血液粘度、促进纤维蛋白溶解、抑制血小板聚集和血栓形成。灯盏花素已被用于研究脑梗死及其后遗症、脑血栓形成、冠心病和心绞痛[1][2]。

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灯盏花素名称

[ CAS 号 ]:
116122-36-2

[ 中文名 ]:
灯盏花素

[ 英文名 ]:
Breviscapin

[英文别名 ]:

Scutellarein-7beta-D-glucuronoside
Breviscapine
Scutellarein-7-glucuronide
Breviscapin
Scutellarein-7beta-D-glucuronide

灯盏花素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Gao J, et al. Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review. Front Pharmacol. 2017 May 23;8:289.

[2]. Wen L, et al. Breviscapine: A Review on its Phytochemistry, Pharmacokinetics and Therapeutic Effects. Am J Chin Med. 2021;49(6):1369-1397.

灯盏花素物理化学性质

[ 密度 ]:
1.81g/cm3

[ 沸点 ]:
891.6ºC at 760mmHg

[ 分子式 ]:
C₅₄H₈₄N₁₆O₂₁

[ 分子量 ]:
1293.34

[ 闪点 ]:
314.9ºC

[ 精确质量 ]:
908.164734

[ PSA ]:
394.47000

[ 蒸汽压 ]:
3.91E-34mmHg at 25°C

[ 折射率 ]:
1.763

[ 储存条件 ]:
2-8°C

灯盏花素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EE4750000

CHEMICAL NAME :: Breviscapine

CAS REGISTRY NUMBER :: 116122-36-2

LAST UPDATED :: 199503

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1314 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 14,33,1983