降脂(植)烷酸

降脂(植)烷酸用途

Pristanic acid是血液中存在的内源性代谢产物,可用于研究α-甲基酰基辅酶A外消旋酶缺乏症和Zellweger综合征[1][2][3]。

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降脂(植)烷酸名称

[ CAS 号 ]:
1189-37-3

[ 中文名 ]:
降脂(植)烷酸

[ 英文名 ]:
pristanic acid

[英文别名 ]:

Pristaninsaeure
acide pristanique
Pristanic acid solution
2,6,10,14-Tetramethyl-pentadecansaeure
2,6,10,14-tetramethylpentadecanoic
acido pristanico
2,6,10,14-Tetramethylpentadecanoic acid
2,6,10,14-tetramethyl-pentadecanoic acid
MFCD05664739

降脂(植)烷酸生物活性

[ 描述 ]:

Pristanic acid是血液中存在的内源性代谢产物,可用于研究α-甲基酰基辅酶A外消旋酶缺乏症和Zellweger综合征[1][2][3]。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

内源性代谢产物被定义为《京都基因和基因组百科全书》注释为我们基因组中约1900种代谢酶的底物或产物。在文献正文中很清楚,许多这些代谢产物都具有毒性[1]。

[参考文献]

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

[2]. McLean BN, et al. A new defect of peroxisomal function involving pristanic acid: a case report. J Neurol Neurosurg Psychiatry. 2002 Mar;72(3):396-9.

[3]. Baumgartner MR, et al. Clinical approach to inherited peroxisomal disorders: a series of 27 patients. Ann Neurol. 1998 Nov;44(5):720-30.

降脂(植)烷酸物理化学性质

[ 密度 ]:
0.882g/cm3

[ 沸点 ]:
408ºC at 760 mmHg

[ 分子式 ]:
C₁₉H₃₈O₂

[ 分子量 ]:
298.50400

[ 闪点 ]:
14ºC

[ 精确质量 ]:
298.28700

[ PSA ]:
37.30000

[ LogP ]:
6.14620

[ 外观性状 ]:
ethanol solution

[ 蒸汽压 ]:
8.48E-08mmHg at 25°C

[ 折射率 ]:
1.453

[ 储存条件 ]:
−20°C

降脂(植)烷酸MSDS

降脂(植)烷酸安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F: Flammable;

[ 风险声明 (欧洲) ]:
R11

[ 安全声明 (欧洲) ]:
S7

[ 危险品运输编码 ]:
UN 1170 3/PG 2

[ WGK德国 ]:
1

降脂(植)烷酸合成路线

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降脂(植)烷酸文献

New insights into the peroxisomal protein inventory: Acyl-CoA oxidases and -dehydrogenases are an ancient feature of peroxisomes.

Biochim. Biophys. Acta 1853(1) , 111-25, (2014)

Peroxisomes are ubiquitous organelles which participate in a variety of essential biochemical pathways. An intimate interrelationship between peroxisomes and mitochondria is emerging in mammals, where...

Peroxisomal bifunctional enzyme deficiency.

J. Clin. Invest. 83(3) , 771-7, (1989)

Peroxisomal function was evaluated in a male infant with clinical features of neonatal adrenoleukodystrophy. Very long chain fatty acid levels were elevated in both plasma and fibroblasts, and beta-ox...

Branched fatty acids in dairy and beef products markedly enhance alpha-methylacyl-CoA racemase expression in prostate cancer cells in vitro.

Cancer Epidemiol. Biomarkers Prev. 12(8) , 775-83, (2003)

An enzyme previously identified as alpha-methylacyl-CoA racemase (AMACR) is overexpressed in high-grade prostatic intraepithelial neoplasia and in a majority (60-100%) of prostate cancers (CaPs) as co...

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