苯醚甲环唑

苯醚甲环唑用途

苯醚甲环唑是一种广谱的三唑类杀菌剂,它通过抑制细胞色素P450依赖的14α-去甲基化作用抑制麦角甾醇的生物合成,从而导致真菌细胞膜破裂和细胞死亡。苯醚甲环唑对禾谷镰刀菌的体外生长有抑制作用(菌丝生长的EC50s=1.69-19.6mg/L)。苯醚甲环唑还可抑制索纳利、富尔瓦、灰葡萄球菌和索拉尼葡萄球菌的生长(EC50s分别为0.131 mg/L、0.069 mg/L、0.297 mg/L和0.252 mg/L)。

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苯醚甲环唑名称

[ CAS 号 ]:
119446-68-3

[ 中文名 ]:
苯醚甲环唑

[ 英文名 ]:
difenoconazole

[中文别名 ]:

[英文别名 ]:

Diflubenzuron
3-chloro-4-[(2RS,4RS
T5O COTJ BR BG DOR DG&& D1 B1- AT5NN DNJ
Difenoconazol
MFCD00144119
difenoconazole

苯醚甲环唑生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 抗感染 >> 真菌

苯醚甲环唑物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
547.0±60.0 °C at 760 mmHg

[ 熔点 ]:
76°C

[ 分子式 ]:
C₁₉H₁₇Cl₂N₃O₃

[ 分子量 ]:
406.263

[ 闪点 ]:
284.6±32.9 °C

[ 精确质量 ]:
405.064697

[ PSA ]:
58.40000

[ LogP ]:
4.92

[ 外观性状 ]:
无色固体

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.642

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
3.3 mg/L (20 ºC)

苯醚甲环唑MSDS

详细MSDS(安全技术说明书)

苯醚甲环唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ4380000

CHEMICAL NAME :: 1H-1,2,4-Triazole, 1-((2-(2-chloro-4-(4-chlorophenoxy)phenyl)-4-methyl-1 ,3-dioxolan-2- yl)methyl)-

CAS REGISTRY NUMBER :: 119446-68-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C19-H17-Cl2-N3-O3

MOLECULAR WEIGHT :: 406.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1453 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,277,1991

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >45 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,277,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2010 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,277,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: >2150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,277,1991

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苯醚甲环唑安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H332-H410

[ 警示性声明 ]:
P273-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R41;R43

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ RTECS号 ]:
XZ4380000

苯醚甲环唑文献

Comparison of greenhouse and field degradation behaviour of isoprocarb, hexaflumuron and difenoconazole in Perilla frutescens.

Bull. Environ. Contam. Toxicol. 89(4) , 868-72, (2012)

Isoprocarb, hexaflumuron and difenoconazole were used in Perilla frutescens at 600, 60 and 75 g a.i./ha respectively. High performance liquid chromatography-tandem mass spectrometry was used for resid...

[Behaviour azole fungicide and fluconazole in Cryptococcus neoformans clinical and environmental isolates].

Rev. Soc. Bras. Med. Trop. 40(2) , 209-11, (2007)

The activity of azole fungicides for agronomical use (epoxiconazole, difenoconazole and cyproconazole) was evaluated in comparison with the therapeutic antifungal agent fluconazole, on 23 environmenta...

Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus.

PLoS ONE 7(3) , e31801, (2012)

Azoles play an important role in the management of Aspergillus diseases. Azole resistance is an emerging global problem in Aspergillus fumigatus, and may develop through patient therapy. In addition, ...

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