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托品醇; 品托碱

托品醇; 品托碱用途

Tropine 是茄科植物的次生代谢产物,是抗胆碱能试剂 (anticholinergic)。Tropine 是合成各种生物活性生物碱的常见中间体,包括 hyoscyamine 和 scopolamine。

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托品醇; 品托碱名称

[ CAS 号 ]:
120-29-6

[ 中文名 ]:
托品醇

[ 英文名 ]:
Tropine

[中文别名 ]:

[英文别名 ]:

(1R,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-ol
8-Methyl-8-azabicyclo[3.2.1]octan-3-ol
Tropine
endo-Tropanol
TROPAN-3ALPHA-OL
3alpha-Tropanol
8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-
EINECS 204-384-2
MFCD00005551
8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-, (1R,5S)-

托品醇; 品托碱生物活性

[ 描述 ]:

Tropine 是茄科植物的次生代谢产物,是抗胆碱能试剂 (anticholinergic)。Tropine 是合成各种生物活性生物碱的常见中间体,包括 hyoscyamine 和 scopolamine。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Grynkiewicz G, et al. Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs.Pharmacol Rep. 2008 Jul-Aug;60(4):439-63.

[2]. Richter U, et al. Overexpression of tropinone reductases alters alkaloid composition in Atropa belladonna root cultures.J Exp Bot. 2005 Feb;56(412):645-52. Epub 2005 Jan 10.

托品醇; 品托碱物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
233.0±0.0 °C at 760 mmHg

[ 熔点 ]:
50-60 °C(lit.)

[ 分子式 ]:
C₈H₁₅NO

[ 分子量 ]:
141.211

[ 闪点 ]:
112.5±14.5 °C

[ 精确质量 ]:
141.115356

[ PSA ]:
23.47000

[ LogP ]:
-0.10

[ 外观性状 ]:
白色至略黄色结晶粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.526

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
100 g/L (20 ºC)

托品醇; 品托碱MSDS

托品醇; 品托碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YM3875000

CHEMICAL NAME :: 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol

CAS REGISTRY NUMBER :: 120-29-6

BEILSTEIN REFERENCE NO. :: 0080188

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H15-N-O

MOLECULAR WEIGHT :: 141.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 139 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANCPAC Annales de Chimie. (Masson et Cie, Paris, France) V.9-15, 1914-77. Volume(issue)/page/year: 7,537,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANCPAC Annales de Chimie. (Masson et Cie, Paris, France) V.9-15, 1914-77. Volume(issue)/page/year: 7,537,1962

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托品醇; 品托碱安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
1544

[ WGK德国 ]:
3

[ RTECS号 ]:
YM3875000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933990090

托品醇; 品托碱合成路线

托品醇; 品托碱上下游产品

托品醇; 品托碱上游产品

托品醇; 品托碱下游产品

托品醇; 品托碱海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

托品醇; 品托碱文献

Tropine dehydrogenase: purification, some properties and an evaluation of its role in the bacterial metabolism of tropine.

Biochem. J. 307 ( Pt 2) , 603-8, (1995)

Tropine dehydrogenase was induced by growth of Pseudomonas AT3 on atropine, tropine or tropinone. It was NADP(+)-dependent and gave no activity with NAD+. The enzyme was very unstable but a rapid puri...

The metabolism of atropine in man.

J. Pharm. Pharmacol. 38(10) , 781-4, (1986)

A metabolic pattern of atropine in man, based on the detection of radiolabelled products in urine by high performance liquid chromatography after administration of [3H]atropine sulphate to a normal vo...

Determination of nitrogen-15 isotope fractionation in tropine: evaluation of extraction protocols for isotope ratio measurement by isotope ratio mass spectrometry.

Rapid Commun. Mass Spectrom. 23(24) , 4031-7, (2009)

N-Demethylation of tropine is an important step in the degradation of this compound and related metabolites. With the purpose of understanding the reaction mechanism(s) involved, it is desirable to me...

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