[(E)-(1-methylpyridin-2-ylidene)methyl]-oxo-azanium; sulfooxymethane

名称

[ CAS 号 ]:
1200-55-1

[ 英文名 ]:
[(E)-(1-methylpyridin-2-ylidene)methyl]-oxo-azanium; sulfooxymethane

[英文别名 ]:

2-Formyl-1-methylpyridinium methyl sulfate oxime
Sulfomethylate de pralidoxime [French]
Contrastigmine
Pralidoxime methyl sulfate
Pyridinium,2-formyl-1-methyl-,methyl sulfate,oxime
Pyridine-2-aldoxime methylsulfate
Contrastigmin
EINECS 214-852-8

物理化学性质

[ 沸点 ]:
189.7ºC at 760 mmHg

[ 分子式 ]:
C₈H₁₂N₂O₅S

[ 分子量 ]:
248.25600

[ 闪点 ]:
68.5ºC

[ 精确质量 ]:
248.04700

[ PSA ]:
111.28000

[ LogP ]:
0.49300

[ 蒸汽压 ]:
0.562mmHg at 25°C

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU4582000

CHEMICAL NAME :: Pyridinium, 2-formyl-1-methyl-, methyl sulfate, oxime

CAS REGISTRY NUMBER :: 1200-55-1

LAST UPDATED :: 198611

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C7-H9-N2-O.C-H3-O4-S

MOLECULAR WEIGHT :: 248.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1716 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 15,1146,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 145 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO. Volume(issue)/page/year: 8,313,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 686 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 15,1146,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 172 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 15,1146,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 172 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 15,1146,1960

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安全信息

[ 海关编码 ]:
2933399090

海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%