HIS-SER-ASP-ALA-LEU-PHE-THR-ASP-THR-TYR-THR-ARG-LEU-ARG-LYS-GLN-MET-ALA-MET-LYS-LYS-TYR-LEU-ASN-SER-VAL-LEU-ASN-NH2: HSDALFTDTYTRLRKQMAMKKYLNSVLN-NH2

用途

VIP(1-12),人、猪、大鼠、羊是血管活性肠肽(VIP)片段。VIP(1-12)、人、猪、大鼠、羊是CD4(T4)/人类免疫缺陷病毒受体的配体[1][2]。

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名称

[ CAS 号 ]:
120928-03-2

[ 中文名 ]:
HIS-SER-ASP-ALA-LEU-PHE-THR-ASP-THR-TYR-THR-ARG-LEU-ARG-LYS-GLN-MET-ALA-MET-LYS-LYS-TYR-LEU-ASN-SER-VAL-LEU-ASN-NH2: HSDALFTDTYTRLRKQMAMKKYLNSVLN-NH2

[ 英文名 ]:
VIP (1-12), human, porcine, rat, ovine

[英文别名 ]:

vip 1-12
HSDAVFTDNYTR
vasoactive intestinal peptide fragment*1-12 human

生物活性

[ 描述 ]:

VIP(1-12),人、猪、大鼠、羊是血管活性肠肽(VIP)片段。VIP(1-12)、人、猪、大鼠、羊是CD4(T4)/人类免疫缺陷病毒受体的配体[1][2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

研究领域 >> 神经疾病

[体内研究]

VIP(1-12)、人、猪、大鼠、羊(1-10μg；ICV)导致大鼠被动回避反应的记忆障碍[1]。动物模型：雄性Wistar大鼠(250 g)[1]剂量：1、2.5、5、10μg给药：侧脑室注射结果：引起反应的剂量依赖性降低。

[参考文献]

[1]. Takashima A, et, al. Vasoactive intestinal peptide (VIP) causes memory impairment in passive avoidance responding of the rat. Peptides. 1993 Oct;14(5):1067-71.

[2]. Sacerdote P, et, al. Vasoactive intestinal peptide 1-12: a ligand for the CD4 (T4)/human immunodeficiency virus receptor. J Neurosci Res. 1987;18(1):102-7.

物理化学性质

[ 分子式 ]:
C₆₁H₈₈N₁₈O₂₂

[ 分子量 ]:
1425.46000

[ 精确质量 ]:
1424.63000

[ PSA ]:
672.61000

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

文献

The entire vasoactive intestinal polypeptide molecule is required for the activation of the vasoactive intestinal polypeptide receptor: functional and binding studies on opossum internal anal sphincter smooth muscle.

J. Pharmacol. Exp. Ther. 266 , 392-399, (1993)

Because no significant information exists regarding the structure-activity of vasoactive intestinal polypeptide (VIP) to gut smooth muscle, we performed functional studies in vitro on opossum internal...

Mechanisms of vasodilation elicited by VIP in sterically stabilized liposomes in vivo.

Am. J. Physiol. 273 , R287-292, (1997)

The purpose of this study was to begin to determine the mechanisms underlying vasodilation elicited by vasoactive intestinal peptide (VIP) in sterically stabilized liposomes (SSL) in the in situ perip...

Vasoactive intestinal peptide 1-12: a ligand for the CD4 (T4)/human immunodeficiency virus receptor.

J. Neurosci. Res. 18 , 102, (1987)

A five-amino-acid (TDNYT) sequence of vasoactive intestinal polypeptide (VIP) shares homology with the proposed attachment sequences of the human immunodeficiency virus (HIV). Synthetic peptides with ...

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