(8Z,11Z,14Z,17Z)-ICOSA-8,11,14,17-四烯酸乙酯

用途

ω-3花生四烯酸乙酯是一种罕见的多不饱和脂肪酸,在膳食中含量很低。众所周知,Omega-3脂肪酸对婴儿的生长发育至关重要,它们可以预防心脏病、血栓、高血压、炎症和自身免疫性疾病。在人类血小板膜中,ω-3花生四烯酸以14μM的Ki抑制花生四烯酸辅酶a合成酶。它还抑制小牛脑提取物中的花生四烯酸辅酶A合成酶,IC50约为5μM。Omega-3乙基花生四烯酸是更亲脂性的游离酸。

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名称

[ CAS 号 ]:
123940-93-2

[ 中文名 ]:
(8Z,11Z,14Z,17Z)-ICOSA-8,11,14,17-四烯酸乙酯

[ 英文名 ]:
ω-3 Arachidonic Acid ethyl ester

[英文别名 ]:

Ethyl (8Z,11Z,14Z,17Z)-8,11,14,17-icosatetraenoate
.ω.-3 Arachidonic Acid ethyl ester

生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
418.1±24.0 °C at 760 mmHg

[ 分子式 ]:
C₂₂H₃₆O₂

[ 分子量 ]:
332.520

[ 闪点 ]:
100.7±21.2 °C

[ 精确质量 ]:
332.271515

[ PSA ]:
26.30000

[ LogP ]:
7.88

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.485

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JX3855100

CHEMICAL NAME :: 8,11,14,17-Eicosatetraenoic acid, ethyl ester, (all Z)-

CAS REGISTRY NUMBER :: 123940-93-2

LAST UPDATED :: 199106

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H36-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 20,801,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 20,801,1989