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左美沙酮

左美沙酮名称

[ CAS 号 ]:
125-58-6

[ 中文名 ]:
左美沙酮

[ 英文名 ]:
(6R)-6-(dimethylamino)-4,4-diphenylheptan-3-one

[英文别名 ]:

Levothyl
Levadone
l-Polamivet
Polamivet
l-methadone
L-Polamidon
Levomethadone

左美沙酮物理化学性质

[ 密度 ]:
1.009g/cm3

[ 沸点 ]:
423.7ºC at 760mmHg

[ 熔点 ]:
99-100ºC

[ 分子式 ]:
C₂₁H₂₇NO

[ 分子量 ]:
309.44500

[ 闪点 ]:
126.5ºC

[ 精确质量 ]:
309.20900

[ PSA ]:
20.31000

[ LogP ]:
4.29200

[ 蒸汽压 ]:
2.2E-07mmHg at 25°C

[ 折射率 ]:
1.538

左美沙酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MJ5990000

CHEMICAL NAME :: 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, L-

CAS REGISTRY NUMBER :: 125-58-6

BEILSTEIN REFERENCE NO. :: 3213668

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C21-H27-N-O

MOLECULAR WEIGHT :: 309.49

WISWESSER LINE NOTATION :: 2VXR&R&1Y1&N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 97 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 26500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1600 ug/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - other effects on male

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - rat Testis

DOSE/DURATION :: 50 umol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 27,123,1978

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左美沙酮安全信息

[ 海关编码 ]:
2922399090

左美沙酮合成路线

详细合成路线

左美沙酮上下游产品

左美沙酮上游产品

左美沙酮下游产品

左美沙酮海关

[ 海关编码 ]: 2922399090

[ 中文概述 ]:
2922399090 其他氨基醛、氨基酮及其盐（包括氨基醌及其盐，但含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%