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丙氯拉嗪乙二磺酸盐

丙氯拉嗪乙二磺酸盐名称

[ CAS 号 ]:
1257-78-9

[ 中文名 ]:
丙氯拉嗪乙二磺酸盐

[ 英文名 ]:
prochlorperazine edisylate

[英文别名 ]:

PROCHLORPERAZINE ETHANE DISULFONATE
prochlorperazine edisylate usp

丙氯拉嗪乙二磺酸盐物理化学性质

[ 沸点 ]:
524.8ºC at 760 mmHg

[ 分子式 ]:
C₂₂H₃₀ClN₃O₆S₃

[ 分子量 ]:
564.13800

[ 闪点 ]:
271.2ºC

[ 精确质量 ]:
563.09900

[ PSA ]:
160.52000

[ LogP ]:
5.44460

[ 蒸汽压 ]:
4.15E-11mmHg at 25°C

[ 储存条件 ]:
2-8℃

丙氯拉嗪乙二磺酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO2975000

CHEMICAL NAME :: Phenothiazine, 2-chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-, ethanedisulfonate

CAS REGISTRY NUMBER :: 1257-78-9

LAST UPDATED :: 199504

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C20-H24-Cl-N3-S.C2-H6-O6-S2

MOLECULAR WEIGHT :: 564.18

WISWESSER LINE NOTATION :: T C666 BN ISJ EG B3- AT6N DNTJ D1 &WSQ2SWQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,40,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 177 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information, see PSCHDL. Volume(issue)/page/year: 12,142,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,40,1972 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 350 mg/kg

SEX/DURATION :: female 7-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - behavioral

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 205,1220,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3225 No. of Facilities: 70 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 4939 (estimated) No. of Female Employees: 4444 (estimated)

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丙氯拉嗪乙二磺酸盐安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ RTECS号 ]:
SO2975000