Althiomycin

Althiomycin用途

Althiomycin, also known as matamycin, is a thiazole antibiotic, effective against Gram-positive and Gram-negative bacteria. Isolated from Streptomyces matensis, Althiomycin was first described by Margalith et al. in 1959. It acts a protein synthesis inhibitor and its site of action is the 50S subunit of the bacterial ribosome.

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Althiomycin名称

[ CAS 号 ]:
12656-40-5

[ 英文名 ]:
Althiomycin

[英文别名 ]:

Matamycin
116-A
althiomycin

Althiomycin物理化学性质

[ 密度 ]:
1.72g/cm3

[ 分子式 ]:
C₁₆H₁₇N₅O₆S₂

[ 分子量 ]:
439.46600

[ 精确质量 ]:
439.06200

[ PSA ]:
207.32000

[ 折射率 ]:
1.768

Althiomycin毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ3500000

CHEMICAL NAME :: 4-Thiazolecarboxamide, N-(1-(4-((2,5-dihydro-4-methoxy-2-oxo-1H-pyrrol-1-yl) carbonyl)-4,5- dihydro-2-thiazolyl)-2-hydroxyethyl)-2-((hydroxyimino )methyl)-

CAS REGISTRY NUMBER :: 12656-40-5

LAST UPDATED :: 198211

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H17-N5-O6-S2

MOLECULAR WEIGHT :: 439.50

WISWESSER LINE NOTATION :: T5N CSJ B1UNQ EVMY1Q- BT5N CSJ EV- AT5NV EHJ DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 720 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,122,1967