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5(6)-羧基-2’,7’-二氯荧光素3’,6’-二乙酸酯

用途

5(6)-羧基-2’,7’-二氯荧光素二乙酸酯是一种细胞渗透荧光指示剂。5(6)-羧基-2',7'-二氯荧光素二乙酸酯可用于评估原代共培养中人类神经胶质(HNG)细胞内ROS的生成[1]

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名称

[ CAS 号 ]:
127770-45-0

[ 中文名 ]:
5[6]-羧基-2’,7’-二氯荧光素二乙酸酯

[ 英文名 ]:
5-(and-6)-carboxy-2`,7`-dichlorofluorescein diacetate

[中文别名 ]:

[英文别名 ]:

生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Pogue AI, et al. Metal-sulfate induced generation of ROS in human brain cells: detection using an isomeric mixture of 5- and 6-carboxy-2',7'-dichlorofluorescein diacetate (carboxy-DCFDA) as a cell permeant tracer. Int J Mol Sci. 2012;13(8):9615-26.

物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
743.3±60.0 °C at 760 mmHg

[ 熔点 ]:
210ºC (dec.)(lit.)

[ 分子式 ]:
C₂₅H₁₄Cl₂O₉

[ 分子量 ]:
529.279

[ 闪点 ]:
403.3±32.9 °C

[ 精确质量 ]:
528.001465

[ PSA ]:
125.43000

[ LogP ]:
3.66

[ 蒸汽压 ]:
0.0±2.6 mmHg at 25°C

[ 折射率 ]:
1.712

[ 储存条件 ]:
-20°C

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

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Prediction of biliary excretion is a challenge for drug discovery scientists due to the lack of in vitro assays. This study explores the possibility of establishing a simple assay to predict in vivo b...

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MRP2 is an efflux transporter that is expressed mainly in the canalicular membrane of hepatocytes, where it expels polar and ionic compounds into the bile. MRP2 is also present in the apical membrane ...

Molecular analysis of the yeast VPS3 gene and the role of its product in vacuolar protein sorting and vacuolar segregation during the cell cycle.

J. Cell Biol. 111 , 877, (1990)

vps3 mutants of the yeast Saccharomyces cerevisiae are impaired in the sorting of newly synthesized soluble vacuolar proteins and in the acidification of the vacuole (Rothman, J. H., and T. H. Stevens...

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