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N-[(4-羟基-3-甲氧基苯基)甲基]-5Z,8Z,11Z,14Z-二十碳烷四氨基

用途

阿伐尼是香草醛受体1(VR1)和大麻素1(CB1)的配体。阿凡尼可以抑制痉挛,作为一种有效的神经保护剂[1]。

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名称

[ CAS 号 ]:
128007-31-8

[ 中文名 ]:
N-[(4-羟基-3-甲氧基苯基)甲基]-5Z,8Z,11Z,14Z-二十碳烷四氨基

[ 英文名 ]:
Arvanil

[英文别名 ]:

N-vanillyl-5Z,8Z,11Z,14Z-eicosatetraenamide
ARVANIL
Picrotoxin
N-arachidonoylvanillamine
N-VANILLYLARACHIDONAMIDE
MFCD01752675

生物活性

[ 描述 ]:

阿伐尼是香草醛受体1(VR1)和大麻素1(CB1)的配体。阿凡尼可以抑制痉挛,作为一种有效的神经保护剂[1]。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体

[ 靶点 ]

VR1, CB1[1]

[参考文献]

[1]. Veldhuis WB, et al. Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases. J Neurosci. 2003;23(10):4127-4133.

物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
619.4±55.0 °C at 760 mmHg

[ 分子式 ]:
C₂₈H₄₁NO₃

[ 分子量 ]:
439.63

[ 闪点 ]:
328.4±31.5 °C

[ 精确质量 ]:
439.308655

[ PSA ]:
58.56000

[ LogP ]:
7.00

[ 外观性状 ]:
液体

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.533

[ 储存条件 ]:
-20°C

MSDS

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JX3845000

CHEMICAL NAME :: 5,8,11,14-Eicosatetraenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-, (all-Z)-

CAS REGISTRY NUMBER :: 128007-31-8

LAST UPDATED :: 199509

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C28-H41-N-O3

MOLECULAR WEIGHT :: 439.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 36,2595,1993

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安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319

[ 警示性声明 ]:
P210-P305 + P351 + P338-P370 + P378-P403 + P235

[ 危险品运输编码 ]:
UN1170 - class 3 - PG 2 - Ethanol

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文献

Genetic background can result in a marked or minimal effect of gene knockout (GPR55 and CB2 receptor) in experimental autoimmune encephalomyelitis models of multiple sclerosis.

PLoS ONE 8 , e76907, (2013)

Endocannabinoids and some phytocannabinoids bind to CB1 and CB2 cannabinoid receptors, transient receptor potential vanilloid one (TRPV1) receptor and the orphan G protein receptor fifty-five (GPR55)....

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