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保泰松钠

保泰松钠用途

【用途一】
解热镇痛药，用于治疗风湿性和类风湿性关节炎及痛风等

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保泰松钠名称

[ CAS 号 ]:
129-18-0

[ 中文名 ]:
保泰松钠

[ 英文名 ]:
phenylbutazone sodium

[中文别名 ]:

4-丁基-1,2-二苯基-3,5-吡唑烷二酮钠盐

[英文别名 ]:

PHENYLBUTAZONE SODIUM
3,5-dioxo-1,2-diphenyl-4-n-butylpyrazolidinsodium
4-BUTYL-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE SODIUM
Einecs 204-935-7
diphenyldioxobutylpyrazolidine-butazolidine-sodium
Phenylbutazone sodium salt
PHENYL BUTAZONE SODIUM SALT
sodiumphenylbutazone
MFCD01749404
UNII:189M850I32

保泰松钠物理化学性质

[ 密度 ]:
1.063 g/mL at 25 °C(lit.)

[ 沸点 ]:
113 °C27 mm Hg(lit.)

[ 分子式 ]:
C₁₉H₁₉N₂NaO₂

[ 分子量 ]:
330.356

[ 闪点 ]:
95 °C

[ 精确质量 ]:
330.134430

[ PSA ]:
49.99000

[ LogP ]:
4.11460

[ 折射率 ]:
n20/D 1.516(lit.)

[ 储存条件 ]:
库房通风低温干燥,与食品原料类分开存放

保泰松钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ8300000

CHEMICAL NAME :: 3,5-Pyrazolidinedione, 4-butyl-1,2-diphenyl-, monosodium salt

CAS REGISTRY NUMBER :: 129-18-0

LAST UPDATED :: 199012

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C19-H20-N2-O2.Na

MOLECULAR WEIGHT :: 331.40

WISWESSER LINE NOTATION :: T5VNNV EHJ BR& CR& E4 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 16 mg/kg/D

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Blood - agranulocytosis Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 855 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 310 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 113 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 476 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 169 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 257 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 94 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 146 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 2160 umol/L

REFERENCE :: HUMAA7 Humangenetik. (Heidelberg, Fed. Rep. Ger.) V.1-30, 1964-75. For publisher information, see HUGEDQ. Volume(issue)/page/year: 12,330,1971

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保泰松钠安全信息

[ 危害码 (欧洲) ]:
C

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S36

[ 海关编码 ]:
2934100090

保泰松钠海关

[ 海关编码 ]: 2934100090

[ 中文概述 ]:
2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%