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噻虫嗪-D3

噻虫嗪-D3用途

噻虫嗪-d3是氘标记的噻虫嗪[1]。噻虫嗪是一种广谱新烟碱类杀虫剂[2][3]。
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噻虫嗪-D3名称

[ CAS 号 ]:
1294048-82-0

[ 中文名 ]:
噻虫嗪-D3

[ 英文名 ]:
Thiamethoxam-d3

[英文别名 ]:

噻虫嗪-D3生物活性

[ 描述 ]:

噻虫嗪-d3是氘标记的噻虫嗪[1]。噻虫嗪是一种广谱新烟碱类杀虫剂[2][3]。

[ 相关类别 ]:

研究领域 >> 其他
信号通路 >> 其他 >> 其他

[体外研究]

氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Lobson C, et al. Fate of thiamethoxam in mesocosms and response of the zooplankton community. Sci Total Environ. 2018 Oct 1;637-638:1150-1157.  

[3]. Ludicke JC, et al. Thiamethoxam impairs honey bee visual learning, alters decision times, and increases abnormal behaviors. Ecotoxicol Environ Saf. 2020 Apr 15193:110367.  

噻虫嗪-D3物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
485.8±55.0 °C at 760 mmHg

[ 分子式 ]:
C8H7ClD3N5O3S

[ 分子量 ]:
294.733

[ 闪点 ]:
247.6±31.5 °C

[ 精确质量 ]:
294.038116

[ PSA ]:
115.02000

[ LogP ]:
-1.16

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.725

噻虫嗪-D3MSDS

噻虫嗪-D3安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H410

[ 警示性声明 ]:
P273-P501

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

噻虫嗪-D3文献

Simultaneous determination of neonicotinoid insecticides in human serum and urine using diatomaceous earth-assisted extraction and liquid chromatography-tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 969 , 85-94, (2014)

A rapid and sensitive analytical method was developed for simultaneous determination of eight neonicotinoid insecticides (acetamiprid, clothianidin, dinotefuran, flonicamid, imidacloprid, nitenpyram, ...

Field-scale examination of neonicotinoid insecticide persistence in soil as a result of seed treatment use in commercial maize (corn) fields in southwestern Ontario.

Environ. Toxicol. Chem. 35 , 295-302, (2016)

Neonicotinoid insecticides, especially as seed treatments, have raised concerns about environmental loading and impacts on pollinators, biodiversity, and ecosystems. The authors measured concentration...

Neonicotinoid insecticide residues in soil dust and associated parent soil in fields with a history of seed treatment use on crops in southwestern Ontario.

Environ. Toxicol. Chem. 35 , 303-10, (2016)

Using neonicotinoid insecticides as seed treatments is a common practice in field crop production. Exposure of nontarget organisms to neonicotinoids present in various environmental matrices is debate...


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