< 生产厂家价格 >

己烯雌酚丙酸酯

己烯雌酚丙酸酯名称

[ CAS 号 ]:
130-80-3

[ 中文名 ]:
丙酸己烯雌酚

[ 英文名 ]:
diethylstilbestrol dipropionate

[英文别名 ]:

Estroben
Desd
Dibestil
cyrenb
Estilbin
Gynolett
Horfemine
Orestol
EINECS 204-995-4
Euvestin

己烯雌酚丙酸酯物理化学性质

[ 密度 ]:
1.075g/cm3

[ 沸点 ]:
486.4ºC at 760mmHg

[ 熔点 ]:
104°

[ 分子式 ]:
C₂₄H₂₈O₄

[ 分子量 ]:
380.47700

[ 闪点 ]:
237ºC

[ 精确质量 ]:
380.19900

[ PSA ]:
52.60000

[ LogP ]:
6.04820

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
1.29E-09mmHg at 25°C

[ 折射率 ]:
1.542

[ 储存条件 ]:
室温

己烯雌酚丙酸酯MSDS

己烯雌酚丙酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WJ5775000

CHEMICAL NAME :: 4,4'-Stilbenediol, alpha,alpha'-diethyl-, dipropionate, (E)-

CAS REGISTRY NUMBER :: 130-80-3

BEILSTEIN REFERENCE NO. :: 2632126

LAST UPDATED :: 199707

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C24-H28-O4

MOLECULAR WEIGHT :: 380.52

WISWESSER LINE NOTATION :: 2VOR DY2&UY2&R DOV2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors Endocrine - changes in growth hormone

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 113 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - other reproductive system tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 133 mg/kg/32W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 60 ug/kg

SEX/DURATION :: female 3-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 500 ug/kg

SEX/DURATION :: female 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 70 ug/kg

SEX/DURATION :: female 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 20 ug/kg

SEX/DURATION :: female 3-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 200 ug/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 200 ng/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 5 mg/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 3,499,1982 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 21,173,1979

点击显示

己烯雌酚丙酸酯安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H312-H332-H350-H360

[ 警示性声明 ]:
P201-P280-P308 + P313

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
45-46-61-20/21/22

[ 安全声明 (欧洲) ]:
S22;S45;S53;S36/S37/S39

[ 危险品运输编码 ]:
UN 3249

[ WGK德国 ]:
3

[ RTECS号 ]:
WJ5775000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2917399090

己烯雌酚丙酸酯合成路线

己烯雌酚丙酸酯海关

[ 海关编码 ]: 2917399090

[ 中文概述 ]:
2917399090 其他芳香多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917399090 aromatic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

己烯雌酚丙酸酯文献

Induction of vitellogenesis in Japanese quail as a sensitive indicator of the estrogen-mimetic effect of a variety of environmental contaminants.

Poult. Sci. 63(8) , 1529-36, (1984)

Vitellogenesis was induced in mature male Japanese quail following intramuscular injections of 16 mumol/100 g body weight of any one of four estrogen analogues or 160 mumol/100 g of the nonsteroid zea...

Effect of diethylstilbestrol and related compounds on the Ca(2+)-transporting ATPase of sarcoplasmic reticulum.

J. Biol. Chem. 267(17) , 11923-9, (1992)

Diethylstilbestrol is a potent inhibitory agent of the Ca(2+)-ATPase activity of sarcoplasmic reticulum membranes. Other structurally related molecules, such as dienestrol or hexestrol having hydroxyl...

Follicular growth patterns in the house rat (Rattus rattus).

Eur. J. Morphol. 31(4) , 257-65, (1993)

A histomorphometrical study has been made of the ovarian follicles in the house rat (Rattus rattus) during estrous cycle, pregnancy and after treatment with FSH, LH and estrogen. The relationships bet...

更多文献