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次硝酸铋

次硝酸铋用途

亚硝酸铋(硝酸氧化铋(III))是一种具有重要医疗用途的铋(III)化合物(例如,用作止泻剂)。亚硝酸铋是一种简单、易得且有效的催化剂,用于末端炔烃的Markovnikov型水合[1]。

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次硝酸铋名称

[ CAS 号 ]:
1304-85-4

[ 中文名 ]:
碱性硝酸铋

[ 英文名 ]:
bismuth nitrate

[中文别名 ]:

[英文别名 ]:

Bismuth(III) subnitrate
Bismuth(3+) trinitrate
Bismuth subnitrate
bismuth nitrate
Bismuth(III) nitrate
EINECS 233-792-3
MFCD00064844

次硝酸铋生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Szécsényi Z, et al. Bismuth Subnitrate-Catalyzed Markovnikov-Type Alkyne Hydrations under Batch and Continuous Flow Conditions. Molecules. 2021;26(10):2864. Published 2021 May 12.

次硝酸铋物理化学性质

[ 密度 ]:
4.928

[ 熔点 ]:
260°C

[ 分子式 ]:
BiN₃O₉

[ 分子量 ]:
394.995

[ 精确质量 ]:
394.943848

[ PSA ]:
206.64000

[ LogP ]:
0.85230

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stability Strong oxidizer - contact with combustible material may lead to fire. Incompatible with reducing agents, organic materials.

次硝酸铋MSDS

详细MSDS(安全技术说明书)

次硝酸铋毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EB2977000

CHEMICAL NAME :: Bismuth hydroxide nitrate oxide

CAS REGISTRY NUMBER :: 1304-85-4

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: Bi5-H9-N4-O22

MOLECULAR WEIGHT :: 1462.03

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 259 mg/kg

TOXIC EFFECTS :: Blood - methemoglobinemia-carboxyhemoglobin

REFERENCE :: JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 133,1280,1947

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,134,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3849 No. of Facilities: 142 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 10190 (estimated) No. of Female Employees: 9898 (estimated)

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次硝酸铋安全信息

[ 符号 ]:

GHS03, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H272-H315-H319-H335

[ 警示性声明 ]:
P210-P220-P221-P305 + P351 + P338-P370 + P378

[ 危害码 (欧洲) ]:
O,Xi

[ 风险声明 (欧洲) ]:
8-36/37/38

[ 安全声明 (欧洲) ]:
S17-S26-S36/37/39

[ 危险品运输编码 ]:
UN 1477 5.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
EB2977000

[ 包装等级 ]:
II

[ 危险类别 ]:
5.1

次硝酸铋制备

1.将五水合硝酸铋加水进行研磨，再慢慢加入氨水，中和游离硝酸，用倾析法洗涤沉淀，吸滤，再用冷水洗涤，干燥，可制得次硝酸铋。
2.将结晶硝酸铋制成悬浮水溶液，加精制碳酸钠溶液或氨水调节，不断搅拌发生反应，将反应产物过滤，经洗涤、干燥即得。
3.在工业中采用复分解法，以硝酸铋加水用氨水或碳酸钠调节ｐＨ＝1.7～1.9进行复分解，反应式如下。

复分解的工艺流程如下。
取结晶硝酸铋［Ｂｉ（ＮＯ３）３·５Ｈ２Ｏ］，加１．５倍量的纯水制成悬浮液，然后快速倾入500L温水（30～35℃）中，加精制碳酸钠溶液或氨水，调节ｐＨ＝1.7～1.9，在不断搅拌下水解15min，然后放料通过高频水改器或磁性水改器，使反应物次铋酸钠粉末疏松而生成微晶，提高临床疗效。由于本制品为一种组分不定的碱式盐，其化学组成随制造过程中的复分解条件不同而不同。如在低温时复分解，化学组成近似于Ｂｉ２Ｏ３·Ｎ２Ｏ５·２Ｈ２Ｏ；而高温下复分解，化学组成近似于２Ｂｉ２Ｏ３·Ｎ２Ｏ５·Ｈ２Ｏ。将复分解产物滤去母液，经温纯水洗涤4次至ｐＨ值约为4时即得。本产品不宜多洗，否则，洗液越洗越酸，出现反常现象。其机理是：进一步水解，游离出硝酸。

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次硝酸铋文献

Bismuth iodoform paraffin paste: a review.

J. Laryngol. Otol. 125(9) , 891-5, (2011)

This article reviews the literature pertaining to bismuth iodoform paraffin paste.Bismuth iodoform paraffin paste is used in most otolaryngology departments on a daily basis. Questions about its prope...

Comparison of the efficacy of cloxacillin alone and cloxacillin combined with an internal teat sealant for dry-cow therapy.

Vet. Rec. 162(21) , 678-84, (2008)

All the quarters in the cows with high somatic cell counts in 10 herds were treated at drying off with either 600 mg cloxacillin or 600 mg cloxacillin and 4 g of an internal teat sealant containing 65...

Physiology of sulfide in the rat colon: use of bismuth to assess colonic sulfide production.

J. Appl. Physiol. 92(4) , 1655-60, (2002)

Colonic bacteria produce hydrogen sulfide, a toxic compound postulated to play a pathogenetic role in ulcerative colitis. Colonic sulfide exposure has previously been assessed via measurements of feca...

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次硝酸铋

次硝酸铋用途

次硝酸铋名称

次硝酸铋生物活性

次硝酸铋物理化学性质

次硝酸铋MSDS

详细MSDS(安全技术说明书)

次硝酸铋毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

次硝酸铋安全信息

次硝酸铋制备

次硝酸铋文献

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