Medphalan

Medphalan名称

[ CAS 号 ]:
13045-94-8

[ 英文名 ]:
Medphalan

[英文别名 ]:

4-[Bis-(2-chlor-aethyl)-amino]-D-phenylalanin
D-Melphalan
Lopac-M-2011
4-(bis(2-chloroethyl)amino)-L-phenylalanine
4-[bis-(2-chloro-ethyl)-amino]-D-phenylalanine
Medphalan
3026 C. B.
p-Di(2-chloroethyl)amino-d-phenylalanine
MFCD01674289
Melphalan Impurity 12

Medphalan物理化学性质

[ 密度 ]:
1.32g/cm3

[ 沸点 ]:
473.1ºC at 760 mmHg

[ 熔点 ]:
182-183ºC (decomp)

[ 分子式 ]:
C₁₃H₁₈Cl₂N₂O₂

[ 分子量 ]:
305.20000

[ 闪点 ]:
239.9ºC

[ 精确质量 ]:
304.07500

[ PSA ]:
66.56000

[ LogP ]:
2.62530

[ 蒸汽压 ]:
9.33E-10mmHg at 25°C

[ 折射率 ]:
1.596

Medphalan毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY3370000

CHEMICAL NAME :: Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, D-

CAS REGISTRY NUMBER :: 13045-94-8

LAST UPDATED :: 199510

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C13-H18-Cl2-N2-O2

MOLECULAR WEIGHT :: 305.23

WISWESSER LINE NOTATION :: QVYZ1R DN2G2G -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 113 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg/9W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

TYPE OF TEST :: Specific locus test

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 10 mmol/L

REFERENCE :: JOGNAU Journal of Genetics. (Belghoria, India) V.1-63, 1910-77. Discontinued. Volume(issue)/page/year: 54,146,1956 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,167,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,167,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987

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Medphalan安全信息

[ 海关编码 ]:
2922499990

Medphalan上下游产品

Medphalan上游产品

Medphalan下游产品

Medphalan海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%