羟基磷灰石

羟基磷灰石用途

Hydroxylapatite (Hydroxyapatite) 是一种天然的磷酸钙,是骨骼和牙齿骨骼的主要矿物成分。纳米 Hydroxylapatite 颗粒由于具有高孔隙度、负电荷和生物降解性,越来越多地被用作药物、蛋白质和核酸等生物活性物质的可控和靶向传递载体。

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羟基磷灰石名称

[ CAS 号 ]:
1306-06-5

[ 中文名 ]:
羟磷灰石

[ 英文名 ]:
Hydroxylapatite

[中文别名 ]:

[英文别名 ]:

Durapatite
Hydroxylapatite
Hydroxyapatite
Monite
MFCD00010904
Calcium hydroxide phosphate (5:1:3)
EINECS 215-145-7

羟基磷灰石生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Moumita Rakshit, et al. Hydroxyapatite Particles Induced Modulation of Collagen Expression and Secretion in Primary Human Dermal Fibroblasts. Int J Nanomedicine. 2020; 15: 4943–4956.

[2]. Yongjia Liu, et al. Hydroxyapatite-Bovine Serum Albumin-Paclitaxel Nanoparticles for Locoregional Treatment of Osteosarcoma. Adv Healthc Mater. 2020 Nov 9;e2000573.

羟基磷灰石物理化学性质

[ 密度 ]:
3.140 g/cm3

[ 沸点 ]:
158ºC at 760 mmHg

[ 熔点 ]:
1100 °C(lit.)

[ 分子式 ]:
Ca₂HO₅P

[ 分子量 ]:
502.311

[ 精确质量 ]:
501.675964

[ PSA ]:
119.12000

[ LogP ]:
0.20920

[ 外观性状 ]:
固体

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: 0.3 mg/mL, clear, colorless

羟基磷灰石MSDS

详细MSDS(安全技术说明书)

羟基磷灰石毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MY8434000

CHEMICAL NAME :: Hydroxylapatite (Ca5(OH)(PO4)3) (9CI)

CAS REGISTRY NUMBER :: 1306-06-5

LAST UPDATED :: 199806

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: Ca5-H-O13-P3

MOLECULAR WEIGHT :: 502.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >25350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >19850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >99500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >25500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >30 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 200 mg/L

REFERENCE :: IJBBBQ Indian Journal of Biochemistry and Biophysics. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.8- 1971- Volume(issue)/page/year: 19,71,1982

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羟基磷灰石安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MY8434000

羟基磷灰石制备

1.将兽类鲜骨经过清洗除杂后，进行蒸制脱除骨胶脂肪，再经干燥、粉碎可制得骨粉。

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羟基磷灰石文献

Biofilm community diversity after exposure to 0·4% stannous fluoride gels.

J. Appl. Microbiol. 117(6) , 1798-809, (2014)

To test the effect of 0·4% stannous fluoride (SnF2 ) glycerine-based gels on specific portions of the bacterial community in both a clinical observational study and in vitro multispecies plaque-derive...

Enhanced enterovirus 71 virus-like particle yield from a new baculovirus design.

Biotechnol. Bioeng. 112 , 2005-15, (2015)

Enterovirus 71 (EV71) is responsible for the outbreaks of hand-foot-and-mouth disease in the Asia-Pacific region. To produce the virus-like particle (VLP) vaccine, we previously constructed recombinan...

Antibacterial and anti-biofilm activity of mouthrinses containing cetylpyridinium chloride and sodium fluoride.

BMC Microbiol. 15 , 169, (2015)

Cetylpyridinium chloride (CPC) and sodium fluoride augment oral hygiene by inactivating bacteria and inhibiting enamel demineralisation, respectively. However, there are few reports in the literature ...

更多文献

羟基磷灰石

羟基磷灰石用途

羟基磷灰石名称

羟基磷灰石生物活性

羟基磷灰石物理化学性质

羟基磷灰石MSDS

详细MSDS(安全技术说明书)

羟基磷灰石毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

羟基磷灰石安全信息

羟基磷灰石制备

羟基磷灰石文献

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