(4S,4aR,7S,7aR,12bS,13S)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9,13-triol

名称

[ 英文名 ]:
(4S,4aR,7S,7aR,12bS,13S)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9,13-triol

[英文别名 ]:

10-Hydroxymorphine

物理化学性质

[ 密度 ]:
1.54g/cm3

[ 沸点 ]:
537.2ºC at 760mmHg

[ 分子式 ]:
C₁₇H₁₉NO₄

[ 分子量 ]:
301.33700

[ 闪点 ]:
278.7ºC

[ 精确质量 ]:
301.13100

[ PSA ]:
73.16000

[ LogP ]:
0.62690

[ 蒸汽压 ]:
2.27E-12mmHg at 25°C

[ 折射率 ]:
1.747

安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

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文献

Impurities in a morphine sulfate drug product identified as 5-(hydroxymethyl)-2-furfural, 10-hydroxymorphine and 10-oxomorphine.

J. Pharm. Sci. 92(3) , 485-93, (2003)

Stability testing of morphine sulfate formulated with nonpareil sugar seeds (consisting of sucrose and starch) and fumaric acid revealed the formation of the three impurities 5-(hydroxymethyl)-2-furfu...

Morphine impurity with opioid activity is identified as 10 alpha-hydroxymorphine.

Pharm. Res. 7(11) , 1205-7, (1990)

Separation of morphine and its oxidation products by capillary zone electrophoresis.

J. Pharm. Biomed. Anal. 20(1-2) , 179-83, (1999)

Separation of morphine and its oxidation products (10-S-hydroxymorphine, pseudomorphine and morphine N-oxide) by capillary zone electrophoresis in Tris-borate buffer in the presence of cyclodextrins w...

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