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7-(β-L-天门冬氨酰氨基)-4-甲基香豆素

7-(β-L-天门冬氨酰氨基)-4-甲基香豆素用途

H-Asp(AMC)-OH是一种氨基酸衍生物,是一种荧光染料。H-Asp(AMC)-OH浓度为0.25mM时不抑制甘氨酸转运[1]。

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7-(β-L-天门冬氨酰氨基)-4-甲基香豆素名称

[ CAS 号 ]:
133628-73-6

[ 中文名 ]:
7-(β-L-天门冬氨酰氨基)-4-甲基香豆素

[ 英文名 ]:
L-Aspartic acid β-(7-amido-4-methylcoumarin)

[中文别名 ]:

7-(Β-L-天门冬氨酰氨基)-4-甲基香豆素

[英文别名 ]:

h-asp(amc)-oh

7-(β-L-天门冬氨酰氨基)-4-甲基香豆素生物活性

[ 描述 ]:

H-Asp(AMC)-OH是一种氨基酸衍生物,是一种荧光染料。H-Asp(AMC)-OH浓度为0.25mM时不抑制甘氨酸转运[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Hatanaka T, et al. Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. J Pharmacol Exp Ther. 2004 Mar;308(3):1138-47.

7-(β-L-天门冬氨酰氨基)-4-甲基香豆素物理化学性质

[ 密度 ]:
1.452g/cm3

[ 沸点 ]:
610ºC at 760mmHg

[ 分子式 ]:
C₁₄H₁₄N₂O₅

[ 分子量 ]:
290.27100

[ 闪点 ]:
322.7ºC

[ 精确质量 ]:
290.09000

[ PSA ]:
122.63000

[ LogP ]:
1.61520

[ 蒸汽压 ]:
9.8E-16mmHg at 25°C

[ 折射率 ]:
1.651

7-(β-L-天门冬氨酰氨基)-4-甲基香豆素MSDS

详细MSDS(安全技术说明书)

7-(β-L-天门冬氨酰氨基)-4-甲基香豆素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22

[ 危险品运输编码 ]:
NONH for all modes of transport

7-(β-L-天门冬氨酰氨基)-4-甲基香豆素文献

Applications of a new fluorimetric enzyme assay for the diagnosis of aspartylglucosaminuria.

J. Inherit. Metab. Dis. 16 , 929-934, (1993)

L-Aspartic acid-beta-7-amido-4-methylcoumarin is a sensitive and specific fluorogenic substrate for lysosomal glycoasparaginase (aspartylglucosaminidase). Fibroblasts and leukocytes from 8 patients wi...

Structural basis of aspartylglucosaminuria.

Biochem. Biophys. Res. Commun. 377 , 1168-1172, (2008)

To elucidate the basis of aspartylglucosaminuria (AGU) from the viewpoint of enzyme structure, we constructed structural models of mutant aspartylglucosaminidase (AGA) proteins using molecular modelin...

Enzymatic diagnosis of aspartylglycosaminuria by fluorometric assay of glycosylasparaginase in serum, plasma, or lymphocytes.

Clin. Chem. 40 , 385-388, (1994)

Serum, plasma, and lymphocytes from aspartylglycosaminuria (AGU) patients and carriers and from normal controls were incubated with a fluorescent glycosylasparaginase substrate, L-aspartic acid beta-(...

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