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8-羟基喹啉硫酸盐

8-羟基喹啉硫酸盐用途

8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) 是单质子双齿螯合剂 (chelating agent), 可用作防腐剂, 消毒剂和杀虫剂, 用作转录抑制剂。

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8-羟基喹啉硫酸盐名称

[ CAS 号 ]:
134-31-6

[ 中文名 ]:
8-羟基喹啉

[ 英文名 ]:
8-Hydroxyquinoline hemisulfate

[中文别名 ]:

[英文别名 ]:

8-Quinolinol, sulfate (2:1) (salt)
MFCD00013095
Bis(8-hydroxyquinolinium) sulphate
8-hydroxyquinoline sulphate
8-Quinolinone Sulfate Monohydrate
EINECS 205-137-1
Oxyquinoline Sulfate
8-Hydroxyquinoline hemisulfate salt
8-Quinolinol hemisulfate salt
Chinosol

8-羟基喹啉硫酸盐生物活性

[ 描述 ]:

8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) 是单质子双齿螯合剂 (chelating agent), 可用作防腐剂, 消毒剂和杀虫剂, 用作转录抑制剂。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

8-羟基喹啉硫酸盐物理化学性质

[ 密度 ]:
1.26g/cm3

[ 沸点 ]:
267ºC at 760 mmHg

[ 熔点 ]:
~175 °C

[ 分子式 ]:
C₉H₇NO_.1/₂H₂O₄S

[ 分子量 ]:
388.394

[ 闪点 ]:
143.1ºC

[ 精确质量 ]:
388.072906

[ PSA ]:
149.22000

[ LogP ]:
4.30880

[ 外观性状 ]:
淡黄色结晶粉末

[ 蒸汽压 ]:
8.34E-14mmHg at 25°C

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
>=10 g/100 mL at 19 ºC

8-羟基喹啉硫酸盐MSDS

详细MSDS(安全技术说明书)

8-羟基喹啉硫酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC8260000

CAS REGISTRY NUMBER :: 134-31-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C18-H14-N2-O2.H2-O4-S

MOLECULAR WEIGHT :: 388.42

WISWESSER LINE NOTATION :: T66 BNJ JQ 2 &WSQQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 umol/L

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 2,191,1980 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81450 No. of Facilities: 669 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 8298 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81450 No. of Facilities: 256 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 4503 (estimated) No. of Female Employees: 3235 (estimated)

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8-羟基喹啉硫酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
1

[ RTECS号 ]:
VC8260000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933499090

8-羟基喹啉硫酸盐海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

8-羟基喹啉硫酸盐文献

Selective growth-inhibitory effect of 8-hydroxyquinoline towards Clostridium difficile and Bifidobacterium longum subsp. longum in co-culture analysed by flow cytometry.

J. Med. Microbiol. 63(Pt 12) , 1663-9, (2014)

The major risk factor for Clostridium difficile infection (CDI) is the use of antibiotics owing to the disruption of the equilibrium of the host gut microbiota. To preserve the beneficial resident pro...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

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