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坡那甾酮A

坡那甾酮A用途

泊那司酮A(25-脱氧半胱氨酸)是一种蜕皮甾体,对蜕皮甾体受体有很强的亲和力。泊那司酮A是细胞和转基因动物中基因表达的有效调节因子,能够快速开启和关闭报告基因[1][2]。

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坡那甾酮A名称

[ CAS 号 ]:
13408-56-5

[ 中文名 ]:
松甾酮A

[ 英文名 ]:
ponasterone A

[中文别名 ]:

[英文别名 ]:

25-Deoxyecdysterone
ponasterone A
25-Deoxy-20-hydroxyecdysone
MFCD00272144

坡那甾酮A生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[ 靶点 ]

ecdysone receptor[2]

[体外研究]

泊那司酮A(1nm-100μM)在CV-1细胞中显示出显著的基因诱导活性[2]。

[体内研究]

泊那司酮A(3-10毫克；i、在反式激活和报告小鼠中产生强大的基因表达诱导[2]。

[参考文献]

[1]. Hansen KØ, et, al. Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum. Molecules. 2018 Jun 19;23(6):1481.

[2]. Gu Y,et, al. Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules. J Biol Chem. 2000 Jun 16;275(24):17917-20.

坡那甾酮A物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
640.5±55.0 °C at 760 mmHg

[ 分子式 ]:
C₂₇H₄₄O₆

[ 分子量 ]:
464.635

[ 闪点 ]:
355.2±28.0 °C

[ 精确质量 ]:
464.313782

[ PSA ]:
118.22000

[ LogP ]:
1.55

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±4.3 mmHg at 25°C

[ 折射率 ]:
1.582

[ 储存条件 ]:
−20°C

坡那甾酮A安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

坡那甾酮A文献

Endogenous CCL2 neutralization restricts HIV-1 replication in primary human macrophages by inhibiting viral DNA accumulation.

Retrovirology 12 , 4, (2015)

Macrophages are key targets of HIV-1 infection. We have previously described that the expression of CC chemokine ligand 2 (CCL2) increases during monocyte differentiation to macrophages and it is furt...

A single-residue change in the HIV-1 V3 loop associated with maraviroc resistance impairs CCR5 binding affinity while increasing replicative capacity.

Retrovirology 12 , 50, (2015)

Maraviroc (MVC) is an allosteric CCR5 inhibitor used against HIV-1 infection. While MVC-resistant viruses have been identified in patients, it still remains incompletely known how they adjust their CD...

Genome-wide promoter binding profiling of protein phosphatase-1 and its major nuclear targeting subunits.

Nucleic Acids Res. 43 , 5771-84, (2015)

Protein phosphatase-1 (PP1) is a key regulator of transcription and is targeted to promoter regions via associated proteins. However, the chromatin binding sites of PP1 have never been studied in a sy...

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