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氯化锰,四水合物

氯化锰,四水合物用途

氯化锰(四水合物),分子生物学等级,≥99.0%(KT)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

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氯化锰,四水合物名称

[ CAS 号 ]:
13446-34-9

[ 中文名 ]:
氯化锰

[ 英文名 ]:
Manganese chloride tetrahydrate

[中文别名 ]:

[英文别名 ]:

Manganese chloride tetrahydrate
MFCD00149792
Manganese(II) chloride tetrahydrate
EINECS 231-869-6

氯化锰,四水合物生物活性

[ 描述 ]:

氯化锰(四水合物),分子生物学等级,≥99.0%(KT)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

氯化锰,四水合物物理化学性质

[ 密度 ]:
2,01 g/cm3

[ 沸点 ]:
1190 °C

[ 熔点 ]:
58 °C(lit.)

[ 分子式 ]:
Cl₂H₈MnO₄

[ 分子量 ]:
197.91

[ 精确质量 ]:
196.91800

[ PSA ]:
36.92000

[ LogP ]:
1.12180

[ 外观性状 ]:
红色固体

[ 储存条件 ]:
库房低温,通风,干燥

[ 稳定性 ]:
Stable. Incompatible with moisture, strong acids, sodium, potassium, zinc.

[ 水溶解性 ]:
1980 g/L (20 ºC)

氯化锰,四水合物MSDS

详细MSDS(安全技术说明书)

氯化锰,四水合物毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OO9650000

CHEMICAL NAME :: Manganese(II) chloride, tetrahydrate

CAS REGISTRY NUMBER :: 13446-34-9

LAST UPDATED :: 199801

DATA ITEMS CITED :: 42

MOLECULAR FORMULA :: Cl2-Mn.4H2-O

MOLECULAR WEIGHT :: 197.92

WISWESSER LINE NOTATION :: MN G2 &QH 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1484 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 10,95,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 138 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 10,95,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JINCAO Journal of Inorganic and Nuclear Chemistry. (Oxford, UK) V.1-43, 1955-81. Volume(issue)/page/year: 41,1507,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 144 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 63,461,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 69,45,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 378 mg/kg/30D-I

TOXIC EFFECTS :: Musculoskeletal - other changes Nutritional and Gross Metabolic - changes in iron Nutritional and Gross Metabolic - changes in metals, not otherwise specified

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 11,515,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 225 mg/kg/15D-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - monoamine oxidase

REFERENCE :: CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year: 6,147,1977

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 324 mg/kg/30D-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Nutritional and Gross Metabolic - changes in sodium Nutritional and Gross Metabolic - changes in metals, not otherwise specified

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 61,227,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 540 mg/kg/90D-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Nutritional and Gross Metabolic - changes in metals, not otherwise specified Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 32,212,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 384 mg/kg/24W-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - sensory change involving peripheral nerve Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 62,148,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 10940 mg/kg/78W-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Biochemical - Neurotransmitters or modulators (putative) - catecholamine levels in CNS Biochemical - Neurotransmitters or modulators (putative) - dopamine in striatum

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 4,189,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 9360 mg/kg/26W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in metals, not otherwise specified Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 24,82,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 156 mg/kg/26W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in metals, not otherwise specified Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 24,75,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 265 mg/kg/3W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport Biochemical - Metabolism (Intermediary) - other proteins

REFERENCE :: IRGGAJ Internationales Archiv fuer Gewerbepathologie und Gewerbehygiene. (Heidelberg, Fed. Rep. Ger.) V.19-25, 1962-69. For publisher information, see IAEHDW. Volume(issue)/page/year: 21,107,1964/1965

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 300 mg/kg/30D-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion)

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 3,249,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 141 gm/kg

SEX/DURATION :: female 90 day(s) pre-mating - 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

REFERENCE :: NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. Volume(issue)/page/year: 5,377,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 47280 ug/kg

SEX/DURATION :: female 6-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 52,109,1995

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 239 mg/kg

SEX/DURATION :: female 8-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JINCAO Journal of Inorganic and Nuclear Chemistry. (Oxford, UK) V.1-43, 1955-81. Volume(issue)/page/year: 41,1507,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 40 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 13,300,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 80 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 69,45,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 105 mg/kg

SEX/DURATION :: male 30 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 32,534,1975 *** REVIEWS *** ACGIH TLV-TWA 0.2 mg(Mn)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:CL 5 mg(Mn)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,149,1971 OSHA PEL (Gen Indu):CL 5 mg(Mn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):CL 5 mg(Mn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):CL 5 mg(Mn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 5 mg(Mn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 mg(Mn)/m3 JAN 1993 OEL-BELGIUM:TWA 5 mg(Mn)/m3 JAN 1993 OEL-DENMARK:TWA 2.5 mg(Mn)/m3 JAN 1993 OEL-FINLAND:TWA 2.5 mg(Mn)/m3 JAN 1993 OEL-HUNGARY:TWA 0.3 mg(Mn)/m3;STEL 0.6 mg(Mn)/m3 JAN 1993 OEL-JAPAN:TWA 0.3 mg(Mn)/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 1 mg(Mn)/m3 JAN 1993 OEL-POLAND:TWA 0.3 mg(Mn)/m3 JAN 1993 OEL-SWEDEN:TWA 1 mg(Mn)/m3;STEL 2.5 mg(Mn)/m3 (resp. dust) JAN 1993 OEL-SWEDEN:TWA 2.5 mg(Mn)/m3;STEL 5 mg(Mn)/m3 (total dust) JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg(Mn)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4985 No. of Facilities: 110 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 3297 (estimated) No. of Female Employees: 1033 (estimated)

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氯化锰,四水合物安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P273

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R48/22;R52

[ 安全声明 (欧洲) ]:
S61-S45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
OO9650000

氯化锰,四水合物制备

1.由菱锰矿粉与盐酸反应，经中和除杂制得。采用软锰矿粉时，一般先还原成一氧化锰，再用盐酸浸取。亦可直接加盐酸反应制得。高纯度氯化锰产品，可用电解金属锰为原料制得。 2.菱锰矿-盐酸法经粉碎的菱锰矿在反应器中与过量盐酸反应完全后，加入石灰进行中和过量盐酸，控制Ph为4左右，加入过氧化氢除去铁。然后在溶液中加入硫酸锰除去钙，净化后的溶液经蒸发、过滤，再蒸发浓缩、冷却结晶、离心分离，制得氯化锰成品。其
3.软锰矿-盐酸法将软锰矿与煤粉混合、还原焙烧生成一氧化锰，或锰矿直接与盐酸反应，经过滤除杂、浓缩、冷却结晶、离心分离，制得氯化锰成品。其
4.将350mL浓盐酸置于烧杯中。在通风橱里，分次少量加入含锰约75%的锰铁粉末共120g，待激烈反应停止后，加420mL水，于水浴上加热4～5h，放置过夜，过滤，滤液中加15g二氧化锰粉，搅拌至溶液中不含Fe2+(可用铁氰化钾检验)。将混合物放置，抽滤，取1/5滤液备用。将122g碳酸钠溶于600mL水中，加热至60℃，注入取出的1/5滤液，生成碳酸锰和氢氧化铁沉淀。用倾泻法洗涤沉淀至洗涤液中不含Cl-。过滤，将此膏状沉淀加入其余的滤液中，加热至50～66℃，充分搅拌使铁完全沉淀(可取少量溶液，过滤后用硫氰酸铵检验)。趁热过滤，滤液加热后重新过滤。将滤液置于水浴上，在低于60℃下浓缩至表面出现结晶薄膜。室温下放置，抽滤。在低于40℃的条件下干燥。储于磨口瓶中。产量200～220g。 5.由重结晶进行精制。如需要更纯的盐时，可用下法除去杂质：将500g硫酸锰溶于水，用硫化氢饱和，滤出沉淀。然后往滤液中加入少量的氨水，并再次用硫化氢饱和，将生成的沉淀进行过滤，继而分别用少量的锰以硫化物形式沉淀两次，并滤出每次的沉淀。用氢氧化钾分别使滤液生成三次，滤出各次生成的沉淀。接着往滤液中加入碳酸铵，使锰沉淀，通过这一操作可除去钾。沉淀经充分洗涤并溶于蒸馏过的硝酸中，所得的硝酸锰用硝酸制成强酸性的溶液，用该溶液再结晶6次，最后两次应在铂皿中进行。所得结晶再溶于水，并再次用碳酸铵(将纯二氧化碳通入在铂皿的蒸馏氨水中制得)使之沉淀，用含有少量氨的水洗涤，以防止碳酸锰胶体化。沉淀在石英容器中溶于蒸馏盐酸，在石英容器中再结晶3次，然后在铂容器中再结晶。产品储存于装有熔融氢氧化钾的干燥器中。

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氯化锰,四水合物文献

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更多文献

氯化锰,四水合物

氯化锰,四水合物用途

氯化锰,四水合物名称

氯化锰,四水合物生物活性

氯化锰,四水合物物理化学性质

氯化锰,四水合物MSDS

详细MSDS(安全技术说明书)

氯化锰,四水合物毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

氯化锰,四水合物安全信息

氯化锰,四水合物制备

氯化锰,四水合物文献

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