福罗帕泛

福罗帕泛用途

Foropafant (SR27417) 是一种高效、竞争性、选择性、可口服的血小板激活因子 (PAF) 受体拮抗剂,抑制 [3H]PAF 与其受体结合,Ki 值为 57 pM,比未被标记的 PAF 低至少 5 倍。Foropafant (SR27417) 有效抑制 PAF 诱导的兔和人血小板聚集。

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福罗帕泛名称

[ CAS 号 ]:
136468-36-5

[ 中文名 ]:
福罗帕泛

[ 英文名 ]:
Foropafant

[英文别名 ]:

MFCD00904759

福罗帕泛生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

[ 靶点 ]

Ki: 57 pM ([3H]PAF binding)[1]

[参考文献]

[1]. Herbert JM, et al. Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. J Pharmacol Exp Ther. 1991 Oct;259(1):44-51.

福罗帕泛物理化学性质

[ 密度 ]:
1.065g/cm3

[ 沸点 ]:
571.6ºC at 760mmHg

[ 分子式 ]:
C₂₈H₄₀N₄S

[ 分子量 ]:
464.70900

[ 闪点 ]:
299.5ºC

[ 精确质量 ]:
464.29700

[ PSA ]:
60.50000

[ LogP ]:
7.14350

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
4.49E-13mmHg at 25°C

[ 折射率 ]:
1.575

[ 储存条件 ]:
-20°C

福罗帕泛MSDS

详细MSDS(安全技术说明书)

福罗帕泛安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

福罗帕泛文献

Platelet-activating factor (PAF) is not an essential component of the cascade leading to smooth muscle cell proliferation following vascular injury.

J. Lipid Mediat. Cell Signal. 12(1) , 49-57, (1995)

In order to evaluate the relative importance platelet-activating factor (PAF) in the proliferative process leading to restenosis, the effect of SR 27417, a novel highly potent PAF receptor antagonist,...

Prevention of platelet-activating factor-induced gastrointestinal lesions in rats by the new specific antagonist N-(2-dimethylaminoethyl)-N-(3-pyridinylmethyl)[4-(2,4,6-triisopropylphe nyl) thiazol-2yl]amine.

Arzneimittelforschung 46(4) , 407-12, (1996)

SR 27417 (CAS 136468-36-5, N-(2-dimethylaminoethyl)-N-(3-pyridinylmethyl)[4-(2,4,6-triisop ropylphenyl) thiazol-2-yl]amine), a highly potent platelet-activating factor (PAF) receptor antagonist, was t...

Role of platelet activating factor in the intestinal epithelial secretory and Chinese hamster ovary cell cytoskeletal responses to cholera toxin.

Proc. Natl. Acad. Sci. U. S. A. 91(20) , 9655-8, (1994)

With the recent heightened concern about cholera around the world come new questions about the mechanism by which cholera toxin causes diarrhea. Peterson and Ochoa have suggested that prostaglandin sy...

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