D-甲状腺素

D-甲状腺素用途

D-甲状腺素(钠)(D-T4(钠))是甲状腺激素的左旋异构体,可用于研究甲状腺功能异常[1][2]。
点击显示

D-甲状腺素名称

[ CAS 号 ]:
137-53-1

[ 中文名 ]:
D-甲状腺素

[ 英文名 ]:
D-THYROXINE SODIUM SALT

[中文别名 ]:

[英文别名 ]:

D-甲状腺素生物活性

[ 描述 ]:

D-甲状腺素(钠)(D-T4(钠))是甲状腺激素的左旋异构体,可用于研究甲状腺功能异常[1][2]。

[ 相关类别 ]:

研究领域 >> 心血管疾病
信号通路 >> 其他 >> 其他

[体外研究]

D-甲状腺素(钠)(D-T4(钠))也影响双羟基香豆素的药理作用[2]。

[体内研究]

D-甲状腺素(钠)(D-T4(钠))抑制小鼠体内双羟基香豆素以及哌替啶和戊巴比妥的代谢[1]。

[参考文献]

[1]. John J. Schrogie M.D., et al. II. The effect of D-thyroxine, clofibrate, and norethandrolone. Clinical Pharmacology and Therapeutics, Volume8, Issue1part1 January 1967 Pages 70-77

[2]. Raluca-IoanaStefan, et al. Simultaneous determination of l-thyroxine (l-T4), d-thyroxine (d-T4), and l-triiodothyronine (l-T3) using a sensors/sequential injection analysis system.

D-甲状腺素物理化学性质

[ 沸点 ]:
576.3ºC at 760mmHg

[ 分子式 ]:
C15H10I4NNaO4

[ 分子量 ]:
798.85200

[ 闪点 ]:
302.3ºC

[ 精确质量 ]:
798.66900

[ PSA ]:
95.61000

[ LogP ]:
3.92290

[ 蒸汽压 ]:
4.02E-14mmHg at 25°C

D-甲状腺素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XP3582990
CHEMICAL NAME :
Thyroxine, monosodium salt, D-
CAS REGISTRY NUMBER :
137-53-1
LAST UPDATED :
199709
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C15-H10-I4-N-O4.Na
MOLECULAR WEIGHT :
798.85
WISWESSER LINE NOTATION :
QR BI FI DOR BI FI D1YZVO &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
12 ug/kg/12D-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse Liver - liver function tests impaired Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
JJMDAT Japanese Journal of Medicine. (Nankodo Co., Ltd., POB 5272, Tokyo International 100-31, Japan) V.1-30, 1962-1991. For publisher information, see IEDIEP. Volume(issue)/page/year: 23,282,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 mg/kg/30D-C
TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 29,207,1970
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
222 mg/kg/24W-C
TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section Kidney, Ureter, Bladder - changes in bladder weight Endocrine - evidence of thyroid hyperfunction
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 29,565,1970 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
29 mg/kg
SEX/DURATION :
female 1-29 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 32,1182,1971
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
15 mg/kg
SEX/DURATION :
female 15-29 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - physical
REFERENCE :
DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 32,1182,1971
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
16 mg/kg
SEX/DURATION :
female 16-31 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
REFERENCE :
SDMEAL South Dakota Journal of Medicine. (South Dakota Medical Assoc., 608 West Ave. N, Sioux Falls, SD 57104) V.18- 1965- Volume(issue)/page/year: 21,33,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5407 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 63 (estimated) No. of Female Employees: 9 (estimated)
点击显示

推荐生产厂家/供应商：

暂无推荐供应商。请联系客服获知如何成为推荐供应商。

相关化合物

【D-甲状腺素】化源网提供D-甲状腺素CAS号137-53-1，D-甲状腺素MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询D-甲状腺素上化源网，专业又轻松。>>电脑版：D-甲状腺素

标题：D-甲状腺素_用途_沸点_分子量_D-甲状腺素CAS号【137-53-1】_化源网 地址：https://m.chemsrc.com/mip/cas/137-53-1_857166.html