< 生产厂家价格 >

RC-3095

RC-3095用途

RC-3095 是一种蛙皮素 (bombesin)/胃泌素 (gastrin) 释放肽受体拮抗剂。

点击显示

RC-3095名称

[ CAS 号 ]:
138147-78-1

[ 中文名 ]:
RC-3095多肽

[ 英文名 ]:
RC-3095

[英文别名 ]:

RC-3095生物活性

[ 描述 ]:

RC-3095 是一种蛙皮素 (bombesin)/胃泌素 (gastrin) 释放肽受体拮抗剂。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> G 蛋白偶联受体/G 蛋白 >> Bombesin Receptor

[参考文献]

[1]. Konturek SJ, et al. Antagonism of receptors for bombesin, gastrin and cholecystokinin in pancreatic secretion and growth. Digestion. 1991;48(2):89-97.

RC-3095物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
1547.9±65.0 °C at 760 mmHg

[ 分子式 ]:
C₅₆H₇₉N₁₅O₉

[ 分子量 ]:
1106.322

[ 闪点 ]:
889.9±34.3 °C

[ 精确质量 ]:
1105.618530

[ LogP ]:
1.05

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.610

[ 储存条件 ]:
-20°C，密封，干燥

RC-3095安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

RC-3095文献

The role of central gastrin-releasing peptide and neuromedin B receptors in the modulation of scratching behavior in rats.

J. Pharmacol. Exp. Ther. 337(3) , 822-9, (2011)

Bombesin is a pruritogenic agent that causes intense itch-scratching activity in rodents. Bombesin has high affinity for the gastrin-releasing peptide (GRP) receptor (GRPr) and the neuromedin B (NMB) ...

Facilitation of the inhibitory transmission by gastrin-releasing peptide in the anterior cingulate cortex.

Mol. Pain 6 , 52, (2010)

Gastrin-releasing peptide (GRP) has been proposed as a peptidergic molecule for behavioral fear and itching. Immunohistochemistry and in situ hybridization studies have shown that GRP and GRP receptor...

New agonist- and antagonist-based treatment approaches for advanced prostate cancer.

J. Int. Med. Res. 40(4) , 1217-26, (2012)

Increased understanding of prostate cancer biology has led to new treatment strategies and promising new agents for treating prostate cancer, in particular peptide-based agonists and antagonists. In t...

更多文献